Cargando…

The bacterial protein toxin, cytotoxic necrotizing factor 1 (CNF1) provides long-term survival in a murine glioma model

BACKGROUND: Glioblastomas are largely unresponsive to all available treatments and there is therefore an urgent need for novel therapeutics. Here we have probed the antineoplastic effects of a bacterial protein toxin, the cytotoxic necrotizing factor 1 (CNF1), in the syngenic GL261 glioma cell model...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vannini, Eleonora, Panighini, Anna, Cerri, Chiara, Fabbri, Alessia, Lisi, Simonetta, Pracucci, Enrico, Benedetto, Nicola, Vannozzi, Riccardo, Fiorentini, Carla, Caleo, Matteo, Costa, Mario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075618/ https://www.ncbi.nlm.nih.gov/pubmed/24939046 http://dx.doi.org/10.1186/1471-2407-14-449

Ejemplares similares

Bacterial Toxins and Targeted Brain Therapy: New Insights from Cytotoxic Necrotizing Factor 1 (CNF1)
por: Tantillo, Elena, et al.
Publicado: (2018)

Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1): Toxin Biology, in Vivo Applications and Therapeutic Potential
por: Fabbri, Alessia, et al.
Publicado: (2010)

Progression of motor deficits in glioma-bearing mice: impact of CNF1 therapy at symptomatic stages
por: Vannini, Eleonora, et al.
Publicado: (2017)

CTX-CNF1 Recombinant Protein Selectively Targets Glioma Cells In Vivo
por: Vannini, Eleonora, et al.
Publicado: (2021)

The bacterial toxin CNF1 as a tool to induce retinal degeneration reminiscent of retinitis pigmentosa
por: Guadagni, Viviana, et al.
Publicado: (2016)

Corrigendum: The bacterial toxin CNF1 as a tool to induce retinal degeneration reminiscent of retinitis pigmentosa
por: Guadagni, Viviana, et al.
Publicado: (2016)

The Rho-activating CNF1 toxin from pathogenic E. coli: A risk factor for human cancer development?
por: Travaglione, Sara, et al.
Publicado: (2008)

Cell-to-Cell Propagation of the Bacterial Toxin CNF1 via Extracellular Vesicles: Potential Impact on the Therapeutic Use of the Toxin
por: Fabbri, Alessia, et al.
Publicado: (2015)

The Bacterial Toxin CNF1 Induces Activation and Maturation of Human Monocyte-Derived Dendritic Cells
por: Gall-Mas, Laura, et al.
Publicado: (2018)

The Cytotoxic Necrotizing Factor 1 from E. Coli: A Janus Toxin Playing with Cancer Regulators
por: Fabbri, Alessia, et al.
Publicado: (2013)

The E. coli CNF1 as a Pioneering Therapy for the Central Nervous System Diseases
por: Travaglione, Sara, et al.
Publicado: (2014)

Effects of the Escherichia coli Bacterial Toxin Cytotoxic Necrotizing Factor 1 on Different Human and Animal Cells: A Systematic Review
por: Carlini, Francesca, et al.
Publicado: (2021)

The Distribution of Cytotoxic Necrotizing Factors (CNF-1, CNF-2, CNF-3) and Cytolethal Distending Toxins (CDT-1, CDT-2, CDT-3, CDT-4) in Escherichia coli Isolates Isolated from Extraintestinal Infections and the Determination of their Phylogenetic Relationship by PFGE
por: Onlen Guneri, Cansu, et al.
Publicado: (2022)

Lu/BCAM Adhesion Glycoprotein Is a Receptor for Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1)
por: Piteau, Marianne, et al.
Publicado: (2014)

Cytotoxic Escherichia coli strains encoding colibactin and cytotoxic necrotizing factor (CNF) colonize laboratory macaques
por: Feng, Yan, et al.
Publicado: (2017)

CNF1 Improves Astrocytic Ability to Support Neuronal Growth and Differentiation In vitro
por: Malchiodi-Albedi, Fiorella, et al.
Publicado: (2012)

Correction: Lu/BCAM Adhesion Glycoprotein Is a Receptor for Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1)
por: Piteau, Marianne, et al.
Publicado: (2014)

High Affinity Binding of Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1) to Lu/BCAM Adhesion Glycoprotein
por: Reppin, Franziska, et al.
Publicado: (2017)

Prevalence and pathologic effects of colibactin and cytotoxic necrotizing factor-1 (Cnf 1) in Escherichia coli: experimental and bioinformatics analyses
por: Morgan, Radwa N., et al.
Publicado: (2019)

Effects of the Rho GTPase‐activating toxin CNF1 on fibroblasts derived from Rett syndrome patients: A pilot study
por: Cittadini, Camilla, et al.
Publicado: (2023)

Analysing the Structural Effect of Point Mutations of Cytotoxic Necrotizing Factor 1 (CNF1) on Lu/BCAM Adhesion Glycoprotein Association
por: de Brevern, Alexandre G.
Publicado: (2018)

Cytotoxic Necrotizing Factor-1 (CNF1) does not promote E. coli infection in a murine model of ascending pyelonephritis
por: Michaud, Jason E., et al.
Publicado: (2017)

The Bacterial Toxin CNF1 Protects Human Neuroblastoma SH-SY5Y Cells against 6-Hydroxydopamine-Induced Cell Damage: The Hypothesis of CNF1-Promoted Autophagy as an Antioxidant Strategy
por: Travaglione, Sara, et al.
Publicado: (2020)

The Bacterial Protein CNF1 as a Potential Therapeutic Strategy against Mitochondrial Diseases: A Pilot Study
por: Fabbri, Alessia, et al.
Publicado: (2018)

Crystal structure of bacterial cytotoxic necrotizing factor CNF(Y) reveals molecular building blocks for intoxication
por: Chaoprasid, Paweena, et al.
Publicado: (2021)

CNF1 Increases Brain Energy Level, Counteracts Neuroinflammatory Markers and Rescues Cognitive Deficits in a Murine Model of Alzheimer's Disease
por: Loizzo, Stefano, et al.
Publicado: (2013)

Correction: CNF1 Increases Brain Energy Level, Counteracts Neuroinflammatory Markers and Rescues Cognitive Deficits in a Murine Model of Alzheimer's Disease
por: Loizzo, Stefano, et al.
Publicado: (2013)

Cnf1 Variants Endowed with the Ability to Cross the Blood–Brain Barrier: A New Potential Therapeutic Strategy for Glioblastoma
por: Colarusso, Andrea, et al.
Publicado: (2020)

Treatment with the Bacterial Toxin CNF1 Selectively Rescues Cognitive and Brain Mitochondrial Deficits in a Female Mouse Model of Rett Syndrome Carrying a MeCP2-Null Mutation
por: Urbinati, Chiara, et al.
Publicado: (2021)

The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNF(Y)) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases
por: Schweer, Janina, et al.
Publicado: (2013)

The bacterial protein CNF1 as a new strategy against Plasmodium falciparum cytoadherence
por: Messina, Valeria, et al.
Publicado: (2019)

Detection of Cyclomodulin CNF-1 Toxin-Producing Strains of Escherichia coli in Pig Kidneys at a Slaughterhouse
por: Herrera-Vázquez, Arturo, et al.
Publicado: (2023)

Loss of CNF(Y) toxin-induced inflammation drives Yersinia pseudotuberculosis into persistency
por: Heine, Wiebke, et al.
Publicado: (2018)

Conformational Insights into the Control of CNF1 Toxin Activity by Peptidyl-Prolyl Isomerization: A Molecular Dynamics Perspective
por: Paillares, Eléa, et al.
Publicado: (2021)

Cross-Activation of Two Nitrogenase Gene Clusters by CnfR1 or CnfR2 in the Cyanobacterium Anabaena variabilis
por: Pratte, Brenda S., et al.
Publicado: (2021)

(1,0)-Super Solutions of (k,s)-CNF Formula
por: Fu, Zufeng, et al.
Publicado: (2020)

CNF1 Enhances Brain Energy Content and Counteracts Spontaneous Epileptiform Phenomena in Aged DBA/2J Mice
por: Travaglione, Sara, et al.
Publicado: (2015)

Electro-cumulation CNF project
por: Grishin, V G
Publicado: (2000)

Interactions of Bacterial Toxin CNF1 and Host JAK1/2 Driven by Liquid-Liquid Phase Separation Enhance Macrophage Polarization
por: Sun, Xuan, et al.
Publicado: (2022)

Cytotoxic Necrotizing Factors (CNFs)−A Growing Toxin Family
por: Knust, Zeynep, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_ea4v2v9u3ev5ifchcb41455tks