Evaluation of the anti–depressant activity of Myristica fragrans (Nutmeg) in male rats

Objective: The present study was undertaken to evaluate anti-depressant activity of Myristica fragrans (MS). Materials and Methods: Male Wistar rats were subjected to imipramine and herbal extract of MS for their antidepressant activity using Forced Swimming Test (FST), Reserpine Reversal Test (RRT)...

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Detalles Bibliográficos
Autores principales: Moinuddin, Ghulam, Devi, Kshama, Kumar Khajuria, Deepak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075663/
https://www.ncbi.nlm.nih.gov/pubmed/25050233
Descripción
Sumario:Objective: The present study was undertaken to evaluate anti-depressant activity of Myristica fragrans (MS). Materials and Methods: Male Wistar rats were subjected to imipramine and herbal extract of MS for their antidepressant activity using Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST). Results: Administration of MS and imipramine revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to the control group. However, there was no significant potentiation of PST. Conclusion: Our study demonstrated the potential antidepressant activity of MS.

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