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Pulmonary function parameters and use of bronchodilators in patients with cystic fibrosis

OBJECTIVE: To analyze pulmonary function parameters and pharmacodynamic response to a bronchodilator, as well as the prescription of bronchodilators, in cystic fibrosis (CF) patients. METHODS: This was a retrospective cohort study involving patients 6-18 years of age, diagnosed with CF, and followed...

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Autores principales: Muramatu, Lucia Harumi, Stirbulov, Roberto, Forte, Wilma Carvalho Neves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Pneumologia e Tisiologia 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075802/
https://www.ncbi.nlm.nih.gov/pubmed/23503485
http://dx.doi.org/10.1590/S1806-37132013000100007
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author Muramatu, Lucia Harumi
Stirbulov, Roberto
Forte, Wilma Carvalho Neves
author_facet Muramatu, Lucia Harumi
Stirbulov, Roberto
Forte, Wilma Carvalho Neves
author_sort Muramatu, Lucia Harumi
collection PubMed
description OBJECTIVE: To analyze pulmonary function parameters and pharmacodynamic response to a bronchodilator, as well as the prescription of bronchodilators, in cystic fibrosis (CF) patients. METHODS: This was a retrospective cohort study involving patients 6-18 years of age, diagnosed with CF, and followed at a referral center between 2008 and 2010. We evaluated only those patients who were able to perform pulmonary function tests (PFTs). We analyzed FVC, FEV(1), and FEF(25-75%), expressed as percentages of the predicted values, prior to and after bronchodilator tests (pre-BD and post-BD, respectively), in 312 PFTs. Repeated measures ANOVA and multiple comparisons were used. RESULTS: The study included 56 patients, divided into two groups: those whose PFT results spanned the 2008-2010 period (n = 37); and those whose PFT results spanned only the 2009-2010 period (n = 19). In the 2008-2010 group, there were significant reductions in post-BD FEV(1) between 2008 and 2010 (p = 0.028) and between 2009 and 2010 (p = 0.036), as was also the case for pre-BD and post-BD FEF(25 75%) in all multiple comparisons (2008 vs. 2009; 2008 vs. 2010; and 2009 vs. 2010). In the 2009-2010 group, there were no significant differences between any of the years for any of the variables studied. Among the 312 PFTs, significant responses to the bronchodilator occurred in only 24 (7.7%), all of which were from patients for whom no bronchodilator had been prescribed during the study period. CONCLUSIONS: In the CF patients studied, there was loss of pulmonary function, indicating progressive lung disease, over time. The changes were greater for FEF(25-75%) than for the other variables, which suggests the initial involvement of small airways.
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spelling pubmed-40758022014-07-16 Pulmonary function parameters and use of bronchodilators in patients with cystic fibrosis Muramatu, Lucia Harumi Stirbulov, Roberto Forte, Wilma Carvalho Neves J Bras Pneumol Original Article OBJECTIVE: To analyze pulmonary function parameters and pharmacodynamic response to a bronchodilator, as well as the prescription of bronchodilators, in cystic fibrosis (CF) patients. METHODS: This was a retrospective cohort study involving patients 6-18 years of age, diagnosed with CF, and followed at a referral center between 2008 and 2010. We evaluated only those patients who were able to perform pulmonary function tests (PFTs). We analyzed FVC, FEV(1), and FEF(25-75%), expressed as percentages of the predicted values, prior to and after bronchodilator tests (pre-BD and post-BD, respectively), in 312 PFTs. Repeated measures ANOVA and multiple comparisons were used. RESULTS: The study included 56 patients, divided into two groups: those whose PFT results spanned the 2008-2010 period (n = 37); and those whose PFT results spanned only the 2009-2010 period (n = 19). In the 2008-2010 group, there were significant reductions in post-BD FEV(1) between 2008 and 2010 (p = 0.028) and between 2009 and 2010 (p = 0.036), as was also the case for pre-BD and post-BD FEF(25 75%) in all multiple comparisons (2008 vs. 2009; 2008 vs. 2010; and 2009 vs. 2010). In the 2009-2010 group, there were no significant differences between any of the years for any of the variables studied. Among the 312 PFTs, significant responses to the bronchodilator occurred in only 24 (7.7%), all of which were from patients for whom no bronchodilator had been prescribed during the study period. CONCLUSIONS: In the CF patients studied, there was loss of pulmonary function, indicating progressive lung disease, over time. The changes were greater for FEF(25-75%) than for the other variables, which suggests the initial involvement of small airways. Sociedade Brasileira de Pneumologia e Tisiologia 2013 /pmc/articles/PMC4075802/ /pubmed/23503485 http://dx.doi.org/10.1590/S1806-37132013000100007 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Muramatu, Lucia Harumi
Stirbulov, Roberto
Forte, Wilma Carvalho Neves
Pulmonary function parameters and use of bronchodilators in patients with cystic fibrosis
title Pulmonary function parameters and use of bronchodilators in patients with cystic fibrosis
title_full Pulmonary function parameters and use of bronchodilators in patients with cystic fibrosis
title_fullStr Pulmonary function parameters and use of bronchodilators in patients with cystic fibrosis
title_full_unstemmed Pulmonary function parameters and use of bronchodilators in patients with cystic fibrosis
title_short Pulmonary function parameters and use of bronchodilators in patients with cystic fibrosis
title_sort pulmonary function parameters and use of bronchodilators in patients with cystic fibrosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075802/
https://www.ncbi.nlm.nih.gov/pubmed/23503485
http://dx.doi.org/10.1590/S1806-37132013000100007
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