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Pulmonary tuberculosis and lung cancer: simultaneous and sequential occurrence

OBJECTIVE: Lung cancer (LC) is the leading cause of cancer-related death and represents a major public health problem worldwide. Another major cause of morbidity and mortality, especially in developing countries, is tuberculosis. The simultaneous or sequential occurrence of pulmonary tuberculosis an...

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Autores principales: Silva, Denise Rossato, Valentini, Dirceu Felipe, Müller, Alice Mânica, de Almeida, Carlos Podalirio Borges, Dalcin, Paulo de Tarso Roth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Pneumologia e Tisiologia 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075860/
https://www.ncbi.nlm.nih.gov/pubmed/24068271
http://dx.doi.org/10.1590/S1806-37132013000400013
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author Silva, Denise Rossato
Valentini, Dirceu Felipe
Müller, Alice Mânica
de Almeida, Carlos Podalirio Borges
Dalcin, Paulo de Tarso Roth
author_facet Silva, Denise Rossato
Valentini, Dirceu Felipe
Müller, Alice Mânica
de Almeida, Carlos Podalirio Borges
Dalcin, Paulo de Tarso Roth
author_sort Silva, Denise Rossato
collection PubMed
description OBJECTIVE: Lung cancer (LC) is the leading cause of cancer-related death and represents a major public health problem worldwide. Another major cause of morbidity and mortality, especially in developing countries, is tuberculosis. The simultaneous or sequential occurrence of pulmonary tuberculosis and LC in the same patient has been reported in various case series and case-control studies. The objective of this study was to describe the characteristics of patients developing tuberculosis and LC, either simultaneously or sequentially. METHODS: This was a cross-sectional study based on the review of medical charts. RESULTS: The study involved 24 patients diagnosed with tuberculosis and LC between 2009 and 2012. The diagnoses of tuberculosis and LC occurred simultaneously in 10 patients, whereas tuberculosis was diagnosed prior to LC in 14. The median time between the two diagnoses was 5 years (interquartile range: 1-30 years). Fourteen patients (58.3%) were male, 20 (83.3%) were White, and 22 (91.7%) were smokers or former smokers. The most common histological type was adenocarcinoma, identified in 14 cases (58.3%), followed by epidermoid carcinoma, identified in 6 (25.0%). Seven patients (29.2%) presented with distant metastases at diagnosis; of those 7 patients, 5 (71%) were diagnosed with LC and tuberculosis simultaneously. CONCLUSIONS: In the present study, most of the patients with tuberculosis and LC were smokers or former smokers, and tuberculosis was diagnosed either before or simultaneously with LC. Non-small cell lung cancer, especially adenocarcinoma, was the most common histological type.
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spelling pubmed-40758602014-07-16 Pulmonary tuberculosis and lung cancer: simultaneous and sequential occurrence Silva, Denise Rossato Valentini, Dirceu Felipe Müller, Alice Mânica de Almeida, Carlos Podalirio Borges Dalcin, Paulo de Tarso Roth J Bras Pneumol Original Articles OBJECTIVE: Lung cancer (LC) is the leading cause of cancer-related death and represents a major public health problem worldwide. Another major cause of morbidity and mortality, especially in developing countries, is tuberculosis. The simultaneous or sequential occurrence of pulmonary tuberculosis and LC in the same patient has been reported in various case series and case-control studies. The objective of this study was to describe the characteristics of patients developing tuberculosis and LC, either simultaneously or sequentially. METHODS: This was a cross-sectional study based on the review of medical charts. RESULTS: The study involved 24 patients diagnosed with tuberculosis and LC between 2009 and 2012. The diagnoses of tuberculosis and LC occurred simultaneously in 10 patients, whereas tuberculosis was diagnosed prior to LC in 14. The median time between the two diagnoses was 5 years (interquartile range: 1-30 years). Fourteen patients (58.3%) were male, 20 (83.3%) were White, and 22 (91.7%) were smokers or former smokers. The most common histological type was adenocarcinoma, identified in 14 cases (58.3%), followed by epidermoid carcinoma, identified in 6 (25.0%). Seven patients (29.2%) presented with distant metastases at diagnosis; of those 7 patients, 5 (71%) were diagnosed with LC and tuberculosis simultaneously. CONCLUSIONS: In the present study, most of the patients with tuberculosis and LC were smokers or former smokers, and tuberculosis was diagnosed either before or simultaneously with LC. Non-small cell lung cancer, especially adenocarcinoma, was the most common histological type. Sociedade Brasileira de Pneumologia e Tisiologia 2013 /pmc/articles/PMC4075860/ /pubmed/24068271 http://dx.doi.org/10.1590/S1806-37132013000400013 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Silva, Denise Rossato
Valentini, Dirceu Felipe
Müller, Alice Mânica
de Almeida, Carlos Podalirio Borges
Dalcin, Paulo de Tarso Roth
Pulmonary tuberculosis and lung cancer: simultaneous and sequential occurrence
title Pulmonary tuberculosis and lung cancer: simultaneous and sequential occurrence
title_full Pulmonary tuberculosis and lung cancer: simultaneous and sequential occurrence
title_fullStr Pulmonary tuberculosis and lung cancer: simultaneous and sequential occurrence
title_full_unstemmed Pulmonary tuberculosis and lung cancer: simultaneous and sequential occurrence
title_short Pulmonary tuberculosis and lung cancer: simultaneous and sequential occurrence
title_sort pulmonary tuberculosis and lung cancer: simultaneous and sequential occurrence
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075860/
https://www.ncbi.nlm.nih.gov/pubmed/24068271
http://dx.doi.org/10.1590/S1806-37132013000400013
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