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The outcome of tuberculosis treatment in subjects with chronic kidney disease in Brazil: a multinomial analysis

OBJECTIVE: To analyze the association between clinical/epidemiological characteristics and outcomes of tuberculosis treatment in patients with concomitant tuberculosis and chronic kidney disease (CKD) in Brazil. METHODS: We used the Brazilian Ministry of Health National Case Registry Database to ide...

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Autores principales: Reis-Santos, Barbara, Gomes, Teresa, Horta, Bernardo Lessa, Maciel, Ethel Leonor Noia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Pneumologia e Tisiologia Paulo 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075878/
https://www.ncbi.nlm.nih.gov/pubmed/24310632
http://dx.doi.org/10.1590/S1806-37132013000500009
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author Reis-Santos, Barbara
Gomes, Teresa
Horta, Bernardo Lessa
Maciel, Ethel Leonor Noia
author_facet Reis-Santos, Barbara
Gomes, Teresa
Horta, Bernardo Lessa
Maciel, Ethel Leonor Noia
author_sort Reis-Santos, Barbara
collection PubMed
description OBJECTIVE: To analyze the association between clinical/epidemiological characteristics and outcomes of tuberculosis treatment in patients with concomitant tuberculosis and chronic kidney disease (CKD) in Brazil. METHODS: We used the Brazilian Ministry of Health National Case Registry Database to identify patients with tuberculosis and CKD, treated between 2007 and 2011. The tuberculosis treatment outcomes were compared with epidemiological and clinical characteristics of the subjects using a hierarchical multinomial logistic regression model, in which cure was the reference outcome. RESULTS: The prevalence of CKD among patients with tuberculosis was 0.4% (95% CI: 0.37-0.42%). The sample comprised 1,077 subjects. The outcomes were cure, in 58%; treatment abandonment, in 7%; death from tuberculosis, in 13%; and death from other causes, in 22%. The characteristics that differentiated the ORs for treatment abandonment or death were age; alcoholism; AIDS; previous noncompliance with treatment; transfer to another facility; suspected tuberculosis on chest X-ray; positive results in the first smear microscopy; and indications for/use of directly observed treatment, short-course strategy. CONCLUSIONS: Our data indicate the importance of sociodemographic characteristics for the diagnosis of tuberculosis in patients with CKD and underscore the need for tuberculosis control strategies targeting patients with chronic noncommunicable diseases, such as CKD.
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spelling pubmed-40758782014-07-16 The outcome of tuberculosis treatment in subjects with chronic kidney disease in Brazil: a multinomial analysis Reis-Santos, Barbara Gomes, Teresa Horta, Bernardo Lessa Maciel, Ethel Leonor Noia J Bras Pneumol Original Articles OBJECTIVE: To analyze the association between clinical/epidemiological characteristics and outcomes of tuberculosis treatment in patients with concomitant tuberculosis and chronic kidney disease (CKD) in Brazil. METHODS: We used the Brazilian Ministry of Health National Case Registry Database to identify patients with tuberculosis and CKD, treated between 2007 and 2011. The tuberculosis treatment outcomes were compared with epidemiological and clinical characteristics of the subjects using a hierarchical multinomial logistic regression model, in which cure was the reference outcome. RESULTS: The prevalence of CKD among patients with tuberculosis was 0.4% (95% CI: 0.37-0.42%). The sample comprised 1,077 subjects. The outcomes were cure, in 58%; treatment abandonment, in 7%; death from tuberculosis, in 13%; and death from other causes, in 22%. The characteristics that differentiated the ORs for treatment abandonment or death were age; alcoholism; AIDS; previous noncompliance with treatment; transfer to another facility; suspected tuberculosis on chest X-ray; positive results in the first smear microscopy; and indications for/use of directly observed treatment, short-course strategy. CONCLUSIONS: Our data indicate the importance of sociodemographic characteristics for the diagnosis of tuberculosis in patients with CKD and underscore the need for tuberculosis control strategies targeting patients with chronic noncommunicable diseases, such as CKD. Sociedade Brasileira de Pneumologia e Tisiologia Paulo 2013 /pmc/articles/PMC4075878/ /pubmed/24310632 http://dx.doi.org/10.1590/S1806-37132013000500009 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Reis-Santos, Barbara
Gomes, Teresa
Horta, Bernardo Lessa
Maciel, Ethel Leonor Noia
The outcome of tuberculosis treatment in subjects with chronic kidney disease in Brazil: a multinomial analysis
title The outcome of tuberculosis treatment in subjects with chronic kidney disease in Brazil: a multinomial analysis
title_full The outcome of tuberculosis treatment in subjects with chronic kidney disease in Brazil: a multinomial analysis
title_fullStr The outcome of tuberculosis treatment in subjects with chronic kidney disease in Brazil: a multinomial analysis
title_full_unstemmed The outcome of tuberculosis treatment in subjects with chronic kidney disease in Brazil: a multinomial analysis
title_short The outcome of tuberculosis treatment in subjects with chronic kidney disease in Brazil: a multinomial analysis
title_sort outcome of tuberculosis treatment in subjects with chronic kidney disease in brazil: a multinomial analysis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075878/
https://www.ncbi.nlm.nih.gov/pubmed/24310632
http://dx.doi.org/10.1590/S1806-37132013000500009
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