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The influence of leptin on Th1/Th2 balance in obese children with asthma
OBJECTIVE: In individuals with asthma, obesity induces the production of leptin and is associated with disease severity. Our objective was to evaluate the levels of serum leptin and their effect on Th1/Th2 balance in obese and non-obese children with asthma, as well as to investigate the association...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Pneumologia e Tisiologia Paulo
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075880/ https://www.ncbi.nlm.nih.gov/pubmed/24310629 http://dx.doi.org/10.1590/S1806-37132013000500006 |
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author | Youssef, Doaa Mohammed Elbehidy, Rabab Mohamed Shokry, Dina Mahamoud Elbehidy, Eman Mohamed |
author_facet | Youssef, Doaa Mohammed Elbehidy, Rabab Mohamed Shokry, Dina Mahamoud Elbehidy, Eman Mohamed |
author_sort | Youssef, Doaa Mohammed |
collection | PubMed |
description | OBJECTIVE: In individuals with asthma, obesity induces the production of leptin and is associated with disease severity. Our objective was to evaluate the levels of serum leptin and their effect on Th1/Th2 balance in obese and non-obese children with asthma, as well as to investigate the association between serum leptin levels and clinical outcomes. METHODS: We evaluated 50 atopic children with physician-diagnosed moderate-to-severe persistent asthma and 20 controls. The children with asthma were divided into two groups, by body mass index percentile: obese (n = 25) and non-obese (n = 25). From all subjects, we collected peripheral blood samples in order to determine the levels of leptin, IFN-γ, and IL-4. Asthma severity was assessed by an asthma symptom score, and the results were correlated with the parameters studied. RESULTS: Serum leptin levels were significantly higher in the obese asthma group than in the non-obese asthma group, as well as being significantly higher in the children with asthma than in the controls, whereas IFN-γ levels were significantly higher and IL-4 levels were significantly lower in the obese asthma group than in the non-obese asthma group. In addition, the obese asthma group showed higher asthma symptom scores and significantly lower FEV(1) (% of predicted) than did the non-obese asthma group. There was a significant positive correlation between leptin and IFN-γ levels only in the obese asthma group. CONCLUSIONS: Although leptin is involved in the pathogenesis of asthma in obese and non-obese children, its effect is more pronounced in the former. In the presence of high leptin levels, only obese children with asthma exhibited Th1 polarization, with higher IFN-γ levels and greater asthma severity. |
format | Online Article Text |
id | pubmed-4075880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Sociedade Brasileira de Pneumologia e Tisiologia Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-40758802014-07-16 The influence of leptin on Th1/Th2 balance in obese children with asthma Youssef, Doaa Mohammed Elbehidy, Rabab Mohamed Shokry, Dina Mahamoud Elbehidy, Eman Mohamed J Bras Pneumol Original Articles OBJECTIVE: In individuals with asthma, obesity induces the production of leptin and is associated with disease severity. Our objective was to evaluate the levels of serum leptin and their effect on Th1/Th2 balance in obese and non-obese children with asthma, as well as to investigate the association between serum leptin levels and clinical outcomes. METHODS: We evaluated 50 atopic children with physician-diagnosed moderate-to-severe persistent asthma and 20 controls. The children with asthma were divided into two groups, by body mass index percentile: obese (n = 25) and non-obese (n = 25). From all subjects, we collected peripheral blood samples in order to determine the levels of leptin, IFN-γ, and IL-4. Asthma severity was assessed by an asthma symptom score, and the results were correlated with the parameters studied. RESULTS: Serum leptin levels were significantly higher in the obese asthma group than in the non-obese asthma group, as well as being significantly higher in the children with asthma than in the controls, whereas IFN-γ levels were significantly higher and IL-4 levels were significantly lower in the obese asthma group than in the non-obese asthma group. In addition, the obese asthma group showed higher asthma symptom scores and significantly lower FEV(1) (% of predicted) than did the non-obese asthma group. There was a significant positive correlation between leptin and IFN-γ levels only in the obese asthma group. CONCLUSIONS: Although leptin is involved in the pathogenesis of asthma in obese and non-obese children, its effect is more pronounced in the former. In the presence of high leptin levels, only obese children with asthma exhibited Th1 polarization, with higher IFN-γ levels and greater asthma severity. Sociedade Brasileira de Pneumologia e Tisiologia Paulo 2013 /pmc/articles/PMC4075880/ /pubmed/24310629 http://dx.doi.org/10.1590/S1806-37132013000500006 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Youssef, Doaa Mohammed Elbehidy, Rabab Mohamed Shokry, Dina Mahamoud Elbehidy, Eman Mohamed The influence of leptin on Th1/Th2 balance in obese children with asthma |
title | The influence of leptin on Th1/Th2 balance in obese
children with asthma
|
title_full | The influence of leptin on Th1/Th2 balance in obese
children with asthma
|
title_fullStr | The influence of leptin on Th1/Th2 balance in obese
children with asthma
|
title_full_unstemmed | The influence of leptin on Th1/Th2 balance in obese
children with asthma
|
title_short | The influence of leptin on Th1/Th2 balance in obese
children with asthma
|
title_sort | influence of leptin on th1/th2 balance in obese
children with asthma |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075880/ https://www.ncbi.nlm.nih.gov/pubmed/24310629 http://dx.doi.org/10.1590/S1806-37132013000500006 |
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