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The influence of leptin on Th1/Th2 balance in obese children with asthma

OBJECTIVE: In individuals with asthma, obesity induces the production of leptin and is associated with disease severity. Our objective was to evaluate the levels of serum leptin and their effect on Th1/Th2 balance in obese and non-obese children with asthma, as well as to investigate the association...

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Autores principales: Youssef, Doaa Mohammed, Elbehidy, Rabab Mohamed, Shokry, Dina Mahamoud, Elbehidy, Eman Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Pneumologia e Tisiologia Paulo 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075880/
https://www.ncbi.nlm.nih.gov/pubmed/24310629
http://dx.doi.org/10.1590/S1806-37132013000500006
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author Youssef, Doaa Mohammed
Elbehidy, Rabab Mohamed
Shokry, Dina Mahamoud
Elbehidy, Eman Mohamed
author_facet Youssef, Doaa Mohammed
Elbehidy, Rabab Mohamed
Shokry, Dina Mahamoud
Elbehidy, Eman Mohamed
author_sort Youssef, Doaa Mohammed
collection PubMed
description OBJECTIVE: In individuals with asthma, obesity induces the production of leptin and is associated with disease severity. Our objective was to evaluate the levels of serum leptin and their effect on Th1/Th2 balance in obese and non-obese children with asthma, as well as to investigate the association between serum leptin levels and clinical outcomes. METHODS: We evaluated 50 atopic children with physician-diagnosed moderate-to-severe persistent asthma and 20 controls. The children with asthma were divided into two groups, by body mass index percentile: obese (n = 25) and non-obese (n = 25). From all subjects, we collected peripheral blood samples in order to determine the levels of leptin, IFN-γ, and IL-4. Asthma severity was assessed by an asthma symptom score, and the results were correlated with the parameters studied. RESULTS: Serum leptin levels were significantly higher in the obese asthma group than in the non-obese asthma group, as well as being significantly higher in the children with asthma than in the controls, whereas IFN-γ levels were significantly higher and IL-4 levels were significantly lower in the obese asthma group than in the non-obese asthma group. In addition, the obese asthma group showed higher asthma symptom scores and significantly lower FEV(1) (% of predicted) than did the non-obese asthma group. There was a significant positive correlation between leptin and IFN-γ levels only in the obese asthma group. CONCLUSIONS: Although leptin is involved in the pathogenesis of asthma in obese and non-obese children, its effect is more pronounced in the former. In the presence of high leptin levels, only obese children with asthma exhibited Th1 polarization, with higher IFN-γ levels and greater asthma severity.
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spelling pubmed-40758802014-07-16 The influence of leptin on Th1/Th2 balance in obese children with asthma Youssef, Doaa Mohammed Elbehidy, Rabab Mohamed Shokry, Dina Mahamoud Elbehidy, Eman Mohamed J Bras Pneumol Original Articles OBJECTIVE: In individuals with asthma, obesity induces the production of leptin and is associated with disease severity. Our objective was to evaluate the levels of serum leptin and their effect on Th1/Th2 balance in obese and non-obese children with asthma, as well as to investigate the association between serum leptin levels and clinical outcomes. METHODS: We evaluated 50 atopic children with physician-diagnosed moderate-to-severe persistent asthma and 20 controls. The children with asthma were divided into two groups, by body mass index percentile: obese (n = 25) and non-obese (n = 25). From all subjects, we collected peripheral blood samples in order to determine the levels of leptin, IFN-γ, and IL-4. Asthma severity was assessed by an asthma symptom score, and the results were correlated with the parameters studied. RESULTS: Serum leptin levels were significantly higher in the obese asthma group than in the non-obese asthma group, as well as being significantly higher in the children with asthma than in the controls, whereas IFN-γ levels were significantly higher and IL-4 levels were significantly lower in the obese asthma group than in the non-obese asthma group. In addition, the obese asthma group showed higher asthma symptom scores and significantly lower FEV(1) (% of predicted) than did the non-obese asthma group. There was a significant positive correlation between leptin and IFN-γ levels only in the obese asthma group. CONCLUSIONS: Although leptin is involved in the pathogenesis of asthma in obese and non-obese children, its effect is more pronounced in the former. In the presence of high leptin levels, only obese children with asthma exhibited Th1 polarization, with higher IFN-γ levels and greater asthma severity. Sociedade Brasileira de Pneumologia e Tisiologia Paulo 2013 /pmc/articles/PMC4075880/ /pubmed/24310629 http://dx.doi.org/10.1590/S1806-37132013000500006 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Youssef, Doaa Mohammed
Elbehidy, Rabab Mohamed
Shokry, Dina Mahamoud
Elbehidy, Eman Mohamed
The influence of leptin on Th1/Th2 balance in obese children with asthma
title The influence of leptin on Th1/Th2 balance in obese children with asthma
title_full The influence of leptin on Th1/Th2 balance in obese children with asthma
title_fullStr The influence of leptin on Th1/Th2 balance in obese children with asthma
title_full_unstemmed The influence of leptin on Th1/Th2 balance in obese children with asthma
title_short The influence of leptin on Th1/Th2 balance in obese children with asthma
title_sort influence of leptin on th1/th2 balance in obese children with asthma
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075880/
https://www.ncbi.nlm.nih.gov/pubmed/24310629
http://dx.doi.org/10.1590/S1806-37132013000500006
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