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Interpretation of autoantibody positivity in interstitial lung disease and lung-dominant connective tissue disease

The initial evaluation of patients with interstitial lung disease (ILD) primarily involves a comprehensive, active search for the cause. Autoantibody assays, which can suggest the presence of a rheumatic disease, are routinely performed at various referral centers. When interstitial lung involvement...

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Detalles Bibliográficos
Autores principales: Pereira, Daniel Antunes Silva, Kawassaki, Alexandre de Melo, Baldi, Bruno Guedes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Pneumologia e Tisiologia 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075893/
https://www.ncbi.nlm.nih.gov/pubmed/24473767
http://dx.doi.org/10.1590/S1806-37132013000600012
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author Pereira, Daniel Antunes Silva
Kawassaki, Alexandre de Melo
Baldi, Bruno Guedes
author_facet Pereira, Daniel Antunes Silva
Kawassaki, Alexandre de Melo
Baldi, Bruno Guedes
author_sort Pereira, Daniel Antunes Silva
collection PubMed
description The initial evaluation of patients with interstitial lung disease (ILD) primarily involves a comprehensive, active search for the cause. Autoantibody assays, which can suggest the presence of a rheumatic disease, are routinely performed at various referral centers. When interstitial lung involvement is the condition that allows the definitive diagnosis of connective tissue disease and the classical criteria are met, there is little debate. However, there is still debate regarding the significance, relevance, specificity, and pathophysiological role of autoimmunity in patients with predominant pulmonary involvement and only mild symptoms or formes frustes of connective tissue disease. The purpose of this article was to review the current knowledge of autoantibody positivity and to discuss its possible interpretations in patients with ILD and without clear etiologic associations, as well as to enhance the understanding of the natural history of an allegedly new disease and to describe the possible prognostic implications. We also discuss the proposition of a new term to be used in the classification of ILDs: lung-dominant connective tissue disease.
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spelling pubmed-40758932014-07-16 Interpretation of autoantibody positivity in interstitial lung disease and lung-dominant connective tissue disease Pereira, Daniel Antunes Silva Kawassaki, Alexandre de Melo Baldi, Bruno Guedes J Bras Pneumol Review Article The initial evaluation of patients with interstitial lung disease (ILD) primarily involves a comprehensive, active search for the cause. Autoantibody assays, which can suggest the presence of a rheumatic disease, are routinely performed at various referral centers. When interstitial lung involvement is the condition that allows the definitive diagnosis of connective tissue disease and the classical criteria are met, there is little debate. However, there is still debate regarding the significance, relevance, specificity, and pathophysiological role of autoimmunity in patients with predominant pulmonary involvement and only mild symptoms or formes frustes of connective tissue disease. The purpose of this article was to review the current knowledge of autoantibody positivity and to discuss its possible interpretations in patients with ILD and without clear etiologic associations, as well as to enhance the understanding of the natural history of an allegedly new disease and to describe the possible prognostic implications. We also discuss the proposition of a new term to be used in the classification of ILDs: lung-dominant connective tissue disease. Sociedade Brasileira de Pneumologia e Tisiologia 2013 /pmc/articles/PMC4075893/ /pubmed/24473767 http://dx.doi.org/10.1590/S1806-37132013000600012 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Pereira, Daniel Antunes Silva
Kawassaki, Alexandre de Melo
Baldi, Bruno Guedes
Interpretation of autoantibody positivity in interstitial lung disease and lung-dominant connective tissue disease
title Interpretation of autoantibody positivity in interstitial lung disease and lung-dominant connective tissue disease
title_full Interpretation of autoantibody positivity in interstitial lung disease and lung-dominant connective tissue disease
title_fullStr Interpretation of autoantibody positivity in interstitial lung disease and lung-dominant connective tissue disease
title_full_unstemmed Interpretation of autoantibody positivity in interstitial lung disease and lung-dominant connective tissue disease
title_short Interpretation of autoantibody positivity in interstitial lung disease and lung-dominant connective tissue disease
title_sort interpretation of autoantibody positivity in interstitial lung disease and lung-dominant connective tissue disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075893/
https://www.ncbi.nlm.nih.gov/pubmed/24473767
http://dx.doi.org/10.1590/S1806-37132013000600012
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