Cargando…

Metformin synergistically enhances antiproliferative effects of cisplatin and etoposide in NCI-H460 human lung cancer cells

OBJECTIVE: To test the effectiveness of combining conventional antineoplastic drugs (cisplatin and etoposide) with metformin in the treatment of non-small cell lung cancer in the NCI-H460 cell line, in order to develop new therapeutic options with high efficacy and low toxicity. METHODS: We used the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Teixeira, Sarah Fernandes, Guimarães, Isabella dos Santos, Madeira, Klesia Pirola, Daltoé, Renata Dalmaschio, Silva, Ian Victor, Rangel, Leticia Batista Azevedo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Sociedade Brasileira de Pneumologia e Tisiologia 2013
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075897/ https://www.ncbi.nlm.nih.gov/pubmed/24473757 http://dx.doi.org/10.1590/S1806-37132013000600002

Ejemplares similares

In vitro antineoplastic activity in triple-negative breast cancer cell line and in vivo
por: Madeira, Klesia, et al.
Publicado: (2014)

Combined anticancer activity of osthole and cisplatin in NCI-H460 lung cancer cells in vitro
por: XU, XIAO-MAN, et al.
Publicado: (2013)

Dihydroberberine exhibits synergistic effects with sunitinib on NSCLC NCI‐H460 cells by repressing MAP kinase pathways and inflammatory mediators
por: Dai, Bingling, et al.
Publicado: (2017)

Sufentanil impairs autophagic degradation and inhibits cell migration in NCI-H460 in vitro
por: Jiang, Hui, et al.
Publicado: (2019)

FIGNL1 is overexpressed in small cell lung cancer patients and enhances NCI-H446 cell resistance to cisplatin and etoposide
por: Ma, Jian, et al.
Publicado: (2017)

Diallyl Trisulfide Inhibits Growth of NCI-H460 in Vitro and in Vivo, and Ameliorates Cisplatin-Induced Oxidative Injury in the Treatment of Lung Carcinoma in Xenograft Mice
por: Jiang, Xiaoyan, et al.
Publicado: (2017)

The synergistic antitumour effect of multi-components from Pulsatilla chinensis saponins in NCI-H460 lung cancer cell line through induction of apoptosis
por: Guan, Ziyi, et al.
Publicado: (2020)

Synergistic Effect of Subtoxic-dose Cisplatin and TRAIL to Mediate Apoptosis by Down-regulating Decoy Receptor 2 and Up-regulating Caspase-8, Caspase-9 and Bax Expression on NCI-H460 and A549 Cells
por: Zhang, Xiaoyan, et al.
Publicado: (2013)

Molecular alterations in apoptotic pathways after PKB/Akt-mediated chemoresistance in NCI H460 cells
por: Hövelmann, S, et al.
Publicado: (2004)

The Side Population in Human Lung Cancer Cell Line NCI-H460 Is Enriched in Stem-Like Cancer Cells
por: Shi, Yang, et al.
Publicado: (2012)

Panobinostat Synergistically Enhances the Cytotoxic Effects of Cisplatin, Doxorubicin or Etoposide on High-Risk Neuroblastoma Cells
por: Wang, Guan, et al.
Publicado: (2013)

An Exceptionally Favorable Response to Etoposide and Cisplatin
por: Valecha, Gautam, et al.
Publicado: (2015)

Pirfenidone Sensitizes NCI-H460 Non-Small Cell Lung Cancer Cells to Paclitaxel and to a Combination of Paclitaxel with Carboplatin
por: Branco, Helena, et al.
Publicado: (2022)

Functional Investigation of NCI-H460-Inducible Myofibroblasts on the Chemoresistance to VP-16 with a Microfluidic 3D Co-Culture Device
por: Hao, Yuanyuan, et al.
Publicado: (2013)

Itraconazole Alters the Stem Cell Characteristics of A549 and NCI-H460 Human Lung Cancer Cells by Suppressing Wnt Signaling
por: Chen, Chuanhui, et al.
Publicado: (2019)

Establishment and Characterization of a Topotecan Resistant Non-small Cell Lung Cancer NCI-H460/TPT10 Cell Line
por: Lei, Zi-Ning, et al.
Publicado: (2020)

A retrospective analysis of clinicopathological and prognostic characteristics of ovarian tumors in the State of Espírito Santo, Brazil
por: Paes, Marcela F, et al.
Publicado: (2011)

Recurrent Metastatic Choriocarcinoma Responsive to Etoposide and Cisplatin with Etoposide, Methotrexate, and Dactinomycin: A Case Report
por: Das, Sunil Kumar, et al.
Publicado: (2022)

Inhibitory effect of ethanol extract of Ocimum sanctum on osteopontin mediated metastasis of NCI-H460 non-small cell lung cancer cells
por: Kwak, Tae-kyung, et al.
Publicado: (2014)

Bufalin Alters Gene Expressions Associated DNA Damage, Cell Cycle, and Apoptosis in Human Lung Cancer NCI-H460 Cells in Vitro
por: Wu, Shin-Hwar, et al.
Publicado: (2014)

An Aqueous Extract of Tuberaria lignosa Inhibits Cell Growth, Alters the Cell Cycle Profile, and Induces Apoptosis of NCI-H460 Tumor Cells
por: Pereira, Joana M., et al.
Publicado: (2016)

Non-small-cell lung cancer cell lines A549 and NCI-H460 express hypoxanthine guanine phosphoribosyltransferase on the plasma membrane
por: Townsend, Michelle H, et al.
Publicado: (2017)

Synthesis of new dihydroberberine and tetrahydroberberine analogues and evaluation of their antiproliferative activity on NCI-H1975 cells
por: Mari, Giacomo, et al.
Publicado: (2020)

Synergistic cytotoxicity of bcl-2 antisense oligodeoxynucleotides and etoposide, doxorubicin and cisplatin on small-cell lung cancer cell lines.
por: Zangemeister-Wittke, U., et al.
Publicado: (1998)

Treatment of poorly differentiated neuroendocrine tumours with etoposide and cisplatin
por: Mitry, E, et al.
Publicado: (1999)

Characterization of etoposide- and cisplatin-chemoresistant retinoblastoma cell lines
por: Busch, Maike, et al.
Publicado: (2018)

Pharmacokinetics and tissue distribution of PGG–paclitaxel, a novel macromolecular formulation of paclitaxel, in nu/nu mice bearing NCI-460 lung cancer xenografts
por: Wang, Xinghe, et al.
Publicado: (2009)

Regulation of voltage-gated potassium channels attenuates resistance of side-population cells to gefitinib in the human lung cancer cell line NCI-H460
por: Choi, Seon Young, et al.
Publicado: (2017)

β-Thujaplicin Enhances TRAIL-Induced Apoptosis via the Dual Effects of XIAP Inhibition and Degradation in NCI-H460 Human Lung Cancer Cells
por: Seno, Saki, et al.
Publicado: (2021)

Osteopontin-c isoform inhibition modulates ovarian cancer cell cisplatin resistance, viability and plasticity
por: Brum, Mariana Concentino Menezes, et al.
Publicado: (2021)

Outcome of treatment with EMA/EP (etoposide methotrexate and actinomycin-D/ etoposide and cisplatin) regimen in gestational trophoblastic neoplasia
por: Aminimoghaddam, Soheila, et al.
Publicado: (2018)

A ZO-1/α5β1-Integrin Complex Regulates Cytokinesis Downstream of PKCε in NCI-H460 Cells Plated on Fibronectin
por: Hämälistö, Saara, et al.
Publicado: (2013)

Luteolin exerts an anticancer effect on NCI-H460 human non-small cell lung cancer cells through the induction of Sirt1-mediated apoptosis
por: MA, LIPING, et al.
Publicado: (2015)

Induction of DNA damage by deguelin is mediated through reducing DNA repair genes in human non-small cell lung cancer NCI-H460 cells
por: JI, BIN-CHUAN, et al.
Publicado: (2012)

Cabozantinib Reverses Topotecan Resistance in Human Non-Small Cell Lung Cancer NCI-H460/TPT10 Cell Line and Tumor Xenograft Model
por: Lei, Zi-Ning, et al.
Publicado: (2021)

Synergistic anti-proliferative and pro-apoptotic activities of 5F and cisplatin in human non-small cell lung cancer NCI-H23 cells
por: Li, Yuchan, et al.
Publicado: (2017)

Polyphenols act synergistically with doxorubicin and etoposide in leukaemia cell lines
por: Mahbub, AA, et al.
Publicado: (2015)

Paclitaxel-etoposide-carboplatin/cisplatin versus etoposide-carboplatin/cisplatin as first-line treatment for combined small-cell lung cancer: a retrospective analysis of 62 cases
por: Li, Yue-Ya, et al.
Publicado: (2015)

A Phase III Randomized Study Comparing a Chemotherapy with Cisplatin and Etoposide to a Etoposide Regimen without Cisplatin for Patients with Extensive Small-Cell Lung Cancer
por: Berghmans, Thierry, et al.
Publicado: (2017)

Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxia
por: Matschke, Johann, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_7n4611kb09l2kor14k6dpk7bh1