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Cas1–Cas2 complex formation mediates spacer acquisition during CRISPR–Cas adaptive immunity

The initial stage of CRISPR–Cas immunity involves the acquisition of foreign DNA spacer segments into the host genomic CRISPR locus. The nucleases Cas1 and Cas2 are the only proteins conserved amongst all CRISPR–Cas systems, yet the molecular functions of these proteins during immunity are unknown....

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Detalles Bibliográficos
Autores principales:	Nuñez, James K., Kranzusch, Philip J., Noeske, Jonas, Wright, Addison V., Davies, Christopher W., Doudna, Jennifer A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075942/ https://www.ncbi.nlm.nih.gov/pubmed/24793649 http://dx.doi.org/10.1038/nsmb.2820

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