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Community-level assessment of dental plaque bacteria susceptibility to triclosan over 19 years

BACKGROUND: Triclosan is a broad-spectrum antimicrobial agent used in toothpaste to reduce dental plaque, gingivitis and oral malodor. This community-level assessment evaluated the susceptibility of dental plaque bacteria to triclosan in samples collected over 19 years. METHODS: A total of 155 denta...

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Autores principales: Haraszthy, Violet I, Sreenivasan, Prem K, Zambon, Joseph J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075995/
https://www.ncbi.nlm.nih.gov/pubmed/24889743
http://dx.doi.org/10.1186/1472-6831-14-61
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author Haraszthy, Violet I
Sreenivasan, Prem K
Zambon, Joseph J
author_facet Haraszthy, Violet I
Sreenivasan, Prem K
Zambon, Joseph J
author_sort Haraszthy, Violet I
collection PubMed
description BACKGROUND: Triclosan is a broad-spectrum antimicrobial agent used in toothpaste to reduce dental plaque, gingivitis and oral malodor. This community-level assessment evaluated the susceptibility of dental plaque bacteria to triclosan in samples collected over 19 years. METHODS: A total of 155 dental plaque samples were collected at eleven different times over 19 years from 58 adults using 0.3% triclosan, 2% copolymer, 0.243% sodium fluoride toothpaste and from 97 adults using toothpaste without triclosan. These included samples from 21 subjects who used triclosan toothpaste for at least five years and samples from 20 control subjects. The samples were cultured on media containing 0, 7.5 or 25 μg/ml triclosan. Descriptive statistics and p values were computed and a linear regression model and the runs test were used to examine susceptibility over time. RESULTS: Growth inhibition averaged 99.451% (91.209 - 99.830%) on media containing 7.5 μg/ml triclosan and 99.989% (99.670 - 100%) on media containing 25 μg/ml triclosan. There was no change in microbial susceptibility to triclosan over time discernible by regression analysis or the runs test in plaque samples taken over 19 years including samples from subjects using a triclosan-containing dentifrice for at least five years. CONCLUSIONS: This community-level assessment of microbial susceptibility to triclosan among supragingival plaque bacteria is consistent with the long-term safety of a 0.3% triclosan, 2% copolymer, 0.243% sodium fluoride dentifrice.
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spelling pubmed-40759952014-07-01 Community-level assessment of dental plaque bacteria susceptibility to triclosan over 19 years Haraszthy, Violet I Sreenivasan, Prem K Zambon, Joseph J BMC Oral Health Research Article BACKGROUND: Triclosan is a broad-spectrum antimicrobial agent used in toothpaste to reduce dental plaque, gingivitis and oral malodor. This community-level assessment evaluated the susceptibility of dental plaque bacteria to triclosan in samples collected over 19 years. METHODS: A total of 155 dental plaque samples were collected at eleven different times over 19 years from 58 adults using 0.3% triclosan, 2% copolymer, 0.243% sodium fluoride toothpaste and from 97 adults using toothpaste without triclosan. These included samples from 21 subjects who used triclosan toothpaste for at least five years and samples from 20 control subjects. The samples were cultured on media containing 0, 7.5 or 25 μg/ml triclosan. Descriptive statistics and p values were computed and a linear regression model and the runs test were used to examine susceptibility over time. RESULTS: Growth inhibition averaged 99.451% (91.209 - 99.830%) on media containing 7.5 μg/ml triclosan and 99.989% (99.670 - 100%) on media containing 25 μg/ml triclosan. There was no change in microbial susceptibility to triclosan over time discernible by regression analysis or the runs test in plaque samples taken over 19 years including samples from subjects using a triclosan-containing dentifrice for at least five years. CONCLUSIONS: This community-level assessment of microbial susceptibility to triclosan among supragingival plaque bacteria is consistent with the long-term safety of a 0.3% triclosan, 2% copolymer, 0.243% sodium fluoride dentifrice. BioMed Central 2014-06-02 /pmc/articles/PMC4075995/ /pubmed/24889743 http://dx.doi.org/10.1186/1472-6831-14-61 Text en Copyright © 2014 Haraszthy et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Haraszthy, Violet I
Sreenivasan, Prem K
Zambon, Joseph J
Community-level assessment of dental plaque bacteria susceptibility to triclosan over 19 years
title Community-level assessment of dental plaque bacteria susceptibility to triclosan over 19 years
title_full Community-level assessment of dental plaque bacteria susceptibility to triclosan over 19 years
title_fullStr Community-level assessment of dental plaque bacteria susceptibility to triclosan over 19 years
title_full_unstemmed Community-level assessment of dental plaque bacteria susceptibility to triclosan over 19 years
title_short Community-level assessment of dental plaque bacteria susceptibility to triclosan over 19 years
title_sort community-level assessment of dental plaque bacteria susceptibility to triclosan over 19 years
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075995/
https://www.ncbi.nlm.nih.gov/pubmed/24889743
http://dx.doi.org/10.1186/1472-6831-14-61
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