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Copper-Catalyzed [(18)F]Fluorination of (Mesityl)(aryl)iodonium Salts
[Image: see text] A practical, rapid, and highly regioselective Cu-catalyzed radiofluorination of (mesityl)(aryl)iodonium salts is described. This protocol utilizes [(18)F]KF to access (18)F-labeled electron-rich, -neutral, and -deficient aryl fluorides under a single set of mild conditions. This me...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical Society
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076000/ https://www.ncbi.nlm.nih.gov/pubmed/24890658 http://dx.doi.org/10.1021/ol501243g |
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author | Ichiishi, Naoko Brooks, Allen F. Topczewski, Joseph J. Rodnick, Melissa E. Sanford, Melanie S. Scott, Peter J. H. |
author_facet | Ichiishi, Naoko Brooks, Allen F. Topczewski, Joseph J. Rodnick, Melissa E. Sanford, Melanie S. Scott, Peter J. H. |
author_sort | Ichiishi, Naoko |
collection | PubMed |
description | [Image: see text] A practical, rapid, and highly regioselective Cu-catalyzed radiofluorination of (mesityl)(aryl)iodonium salts is described. This protocol utilizes [(18)F]KF to access (18)F-labeled electron-rich, -neutral, and -deficient aryl fluorides under a single set of mild conditions. This methodology is applied to the synthesis of protected versions of two important radiotracers: 4-[(18)F]fluorophenylalanine and 6-[(18)F]fluoroDOPA. |
format | Online Article Text |
id | pubmed-4076000 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | American
Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-40760002015-06-03 Copper-Catalyzed [(18)F]Fluorination of (Mesityl)(aryl)iodonium Salts Ichiishi, Naoko Brooks, Allen F. Topczewski, Joseph J. Rodnick, Melissa E. Sanford, Melanie S. Scott, Peter J. H. Org Lett [Image: see text] A practical, rapid, and highly regioselective Cu-catalyzed radiofluorination of (mesityl)(aryl)iodonium salts is described. This protocol utilizes [(18)F]KF to access (18)F-labeled electron-rich, -neutral, and -deficient aryl fluorides under a single set of mild conditions. This methodology is applied to the synthesis of protected versions of two important radiotracers: 4-[(18)F]fluorophenylalanine and 6-[(18)F]fluoroDOPA. American Chemical Society 2014-06-03 2014-06-20 /pmc/articles/PMC4076000/ /pubmed/24890658 http://dx.doi.org/10.1021/ol501243g Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) |
spellingShingle | Ichiishi, Naoko Brooks, Allen F. Topczewski, Joseph J. Rodnick, Melissa E. Sanford, Melanie S. Scott, Peter J. H. Copper-Catalyzed [(18)F]Fluorination of (Mesityl)(aryl)iodonium Salts |
title | Copper-Catalyzed [(18)F]Fluorination of (Mesityl)(aryl)iodonium
Salts |
title_full | Copper-Catalyzed [(18)F]Fluorination of (Mesityl)(aryl)iodonium
Salts |
title_fullStr | Copper-Catalyzed [(18)F]Fluorination of (Mesityl)(aryl)iodonium
Salts |
title_full_unstemmed | Copper-Catalyzed [(18)F]Fluorination of (Mesityl)(aryl)iodonium
Salts |
title_short | Copper-Catalyzed [(18)F]Fluorination of (Mesityl)(aryl)iodonium
Salts |
title_sort | copper-catalyzed [(18)f]fluorination of (mesityl)(aryl)iodonium
salts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076000/ https://www.ncbi.nlm.nih.gov/pubmed/24890658 http://dx.doi.org/10.1021/ol501243g |
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