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Copper-Catalyzed [(18)F]Fluorination of (Mesityl)(aryl)iodonium Salts

[Image: see text] A practical, rapid, and highly regioselective Cu-catalyzed radiofluorination of (mesityl)(aryl)iodonium salts is described. This protocol utilizes [(18)F]KF to access (18)F-labeled electron-rich, -neutral, and -deficient aryl fluorides under a single set of mild conditions. This me...

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Autores principales: Ichiishi, Naoko, Brooks, Allen F., Topczewski, Joseph J., Rodnick, Melissa E., Sanford, Melanie S., Scott, Peter J. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076000/
https://www.ncbi.nlm.nih.gov/pubmed/24890658
http://dx.doi.org/10.1021/ol501243g
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author Ichiishi, Naoko
Brooks, Allen F.
Topczewski, Joseph J.
Rodnick, Melissa E.
Sanford, Melanie S.
Scott, Peter J. H.
author_facet Ichiishi, Naoko
Brooks, Allen F.
Topczewski, Joseph J.
Rodnick, Melissa E.
Sanford, Melanie S.
Scott, Peter J. H.
author_sort Ichiishi, Naoko
collection PubMed
description [Image: see text] A practical, rapid, and highly regioselective Cu-catalyzed radiofluorination of (mesityl)(aryl)iodonium salts is described. This protocol utilizes [(18)F]KF to access (18)F-labeled electron-rich, -neutral, and -deficient aryl fluorides under a single set of mild conditions. This methodology is applied to the synthesis of protected versions of two important radiotracers: 4-[(18)F]fluorophenylalanine and 6-[(18)F]fluoroDOPA.
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spelling pubmed-40760002015-06-03 Copper-Catalyzed [(18)F]Fluorination of (Mesityl)(aryl)iodonium Salts Ichiishi, Naoko Brooks, Allen F. Topczewski, Joseph J. Rodnick, Melissa E. Sanford, Melanie S. Scott, Peter J. H. Org Lett [Image: see text] A practical, rapid, and highly regioselective Cu-catalyzed radiofluorination of (mesityl)(aryl)iodonium salts is described. This protocol utilizes [(18)F]KF to access (18)F-labeled electron-rich, -neutral, and -deficient aryl fluorides under a single set of mild conditions. This methodology is applied to the synthesis of protected versions of two important radiotracers: 4-[(18)F]fluorophenylalanine and 6-[(18)F]fluoroDOPA. American Chemical Society 2014-06-03 2014-06-20 /pmc/articles/PMC4076000/ /pubmed/24890658 http://dx.doi.org/10.1021/ol501243g Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html)
spellingShingle Ichiishi, Naoko
Brooks, Allen F.
Topczewski, Joseph J.
Rodnick, Melissa E.
Sanford, Melanie S.
Scott, Peter J. H.
Copper-Catalyzed [(18)F]Fluorination of (Mesityl)(aryl)iodonium Salts
title Copper-Catalyzed [(18)F]Fluorination of (Mesityl)(aryl)iodonium Salts
title_full Copper-Catalyzed [(18)F]Fluorination of (Mesityl)(aryl)iodonium Salts
title_fullStr Copper-Catalyzed [(18)F]Fluorination of (Mesityl)(aryl)iodonium Salts
title_full_unstemmed Copper-Catalyzed [(18)F]Fluorination of (Mesityl)(aryl)iodonium Salts
title_short Copper-Catalyzed [(18)F]Fluorination of (Mesityl)(aryl)iodonium Salts
title_sort copper-catalyzed [(18)f]fluorination of (mesityl)(aryl)iodonium salts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076000/
https://www.ncbi.nlm.nih.gov/pubmed/24890658
http://dx.doi.org/10.1021/ol501243g
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