A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1

[Image: see text] Lysine-specific demethylase 1 (LSD1) is an epigenetic enzyme that oxidatively cleaves methyl groups from monomethyl and dimethyl Lys4 of histone H3 (H3K4Me1, H3K4Me2) and can contribute to gene silencing. This study describes the design and synthesis of analogues of a monoamine oxi...

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Detalles Bibliográficos
Autores principales: Prusevich, Polina, Kalin, Jay H., Ming, Shonoi A., Basso, Manuela, Givens, Jeffrey, Li, Xin, Hu, Jianfei, Taylor, Martin S., Cieniewicz, Anne M., Hsiao, Po-Yuan, Huang, Rong, Roberson, Heather, Adejola, Nkosi, Avery, Lindsay B., Casero, Robert A., Taverna, Sean D., Qian, Jiang, Tackett, Alan J., Ratan, Rajiv R., McDonald, Oliver G., Feinberg, Andrew P., Cole, Philip A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076021/
https://www.ncbi.nlm.nih.gov/pubmed/24707965
http://dx.doi.org/10.1021/cb500018s

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076021/
https://www.ncbi.nlm.nih.gov/pubmed/24707965
http://dx.doi.org/10.1021/cb500018s

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