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Soluble Phosphatidylserine Binds to Two Sites on Human Factor IXa in a Ca(2+) Dependent Fashion to Specifically Regulate Structure and Activity
Clinical studies have demonstrated a correlation between elevated levels of FIX and the risk of coronary heart disease, while reduced plasma FIX causes hemophilia B. FIXa interacts with FVIIIa in the presence of Ca(2+) and phosphatidylserine (PS)-containing membranes to form a factor X-activating co...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076177/ https://www.ncbi.nlm.nih.gov/pubmed/24979705 http://dx.doi.org/10.1371/journal.pone.0100006 |