Cargando…

A Herpes Simplex Virus 2 (HSV-2) Glycoprotein D-expressing Nonreplicating Dominant-Negative HSV-2 Virus Vaccine Is Superior to a gD2 Subunit Vaccine against HSV-2 Genital Infection in Guinea Pigs

We recently constructed a novel non-replicating dominant-negative HSV-2 recombinant viral vaccine (CJ2-gD2) capable of expressing various HSV-2 antigens that are dominant targets of HSV-2-specific CD8 T-cell response. Importantly, CJ2-gD2 expresses gD2, the HSV-2 major antigen glycoprotein D, as eff...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Pengwei, Xie, Lining, Balliet, John W., Casimiro, Danilo R., Yao, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076306/ https://www.ncbi.nlm.nih.gov/pubmed/24979708 http://dx.doi.org/10.1371/journal.pone.0101373

Ejemplares similares

Antibody to HSV gD peptide induced by vaccination does not protect against HSV-2 infection in HSV-2 seronegative women
por: Gilbert, Peter B., et al.
Publicado: (2017)

Immunization with a dominant-negative recombinant Herpes Simplex Virus (HSV) type 1 protects against HSV-2 genital disease in guinea pigs
por: Brans, Richard, et al.
Publicado: (2010)

A Replication-Defective Herpes Simplex Virus (HSV)-2 Vaccine, HSV529, is Safe and Well-Tolerated in Adults with or without HSV Infection and Induces Significant HSV-2-Specific Antibody Responses in HSV Seronegative Individuals
por: Dropulic, Lesia, et al.
Publicado: (2017)

The population impact of herpes simplex virus type 2 (HSV-2) vaccination on the incidence of HSV-2, HIV and genital ulcer disease in South Africa: a mathematical modelling study
por: Stone, Jack, et al.
Publicado: (2023)

An Adenovirus-Based Recombinant Herpes Simplex Virus 2 (HSV-2) Therapeutic Vaccine Is Highly Protective against Acute and Recurrent HSV-2 Disease in a Guinea Pig Model
por: Wan, Mingming, et al.
Publicado: (2023)

Assessment of Two Novel Live-Attenuated Vaccine Candidates for Herpes Simplex Virus 2 (HSV-2) in Guinea Pigs
por: Joyce, Jonathan D., et al.
Publicado: (2021)

Herpes Simplex Virus 2 (HSV-2) Infected Cell Proteins Are among the Most Dominant Antigens of a Live-Attenuated HSV-2 Vaccine
por: Geltz, Joshua J., et al.
Publicado: (2015)

The R2 non-neuroinvasive HSV-1 vaccine affords protection from genital HSV-2 infections in a guinea pig model
por: Bernstein, David I., et al.
Publicado: (2020)

Herpes simplex virus type 2 trivalent protein vaccine containing glycoproteins C, D and E protects guinea pigs against HSV-1 genital infection
por: Egan, Kevin, et al.
Publicado: (2020)

Comparative Evaluation of AmpliVue HSV 1+2 Assay with ELVIS Culture for Detecting Herpes Simplex Virus 1 (HSV-1) and HSV-2 in Clinical Specimens
por: Granato, Paul A., et al.
Publicado: (2015)

Persistence of mucosal T cell responses to herpes simplex virus type 2 (HSV-2) in the female genital tract
por: Posavad, Christine M., et al.
Publicado: (2014)

An HSV-2 nucleoside-modified mRNA genital herpes vaccine containing glycoproteins gC, gD, and gE protects mice against HSV-1 genital lesions and latent infection
por: Egan, Kevin P., et al.
Publicado: (2020)

Pan-HSV-2 IgG Antibody in Vaccinated Mice and Guinea Pigs Correlates with Protection against Herpes Simplex Virus 2
por: Halford, William P., et al.
Publicado: (2013)

Herpes simplex virus 2 (HSV-2) evolves faster in cell culture than HSV-1 by generating greater genetic diversity
por: López-Muñoz, Alberto Domingo, et al.
Publicado: (2021)

A Trivalent HSV-2 gC2, gD2, gE2 Nucleoside-Modified mRNA-LNP Vaccine Provides Outstanding Protection in Mice against Genital and Non-Genital HSV-1 Infection, Comparable to the Same Antigens Derived from HSV-1
por: Egan, Kevin P., et al.
Publicado: (2023)

Herpes Simplex Virus Mistyping due to HSV-1 × HSV-2 Interspecies Recombination in Viral Gene Encoding Glycoprotein B
por: Casto, Amanda M., et al.
Publicado: (2020)

Virus-Specific Immune Memory at Peripheral Sites of Herpes Simplex Virus Type 2 (HSV-2) Infection in Guinea Pigs
por: Xia, Jingya, et al.
Publicado: (2014)

Enrichment of herpes simplex virus type 2 (HSV-2) reactive mucosal T cells in the human female genital tract
por: Posavad, Christine M., et al.
Publicado: (2017)

Effect of Copper Acyclovir Complexes on Herpes Simplex Virus Type 1 and Type 2 (HSV-1, HSV-2) Infection in Cultured Cells
por: Panteva, M., et al.
Publicado: (1998)

Novel Adjuvant S-540956 Targets Lymph Nodes and Reduces Genital Recurrences and Vaginal Shedding of HSV-2 DNA When Administered with HSV-2 Glycoprotein D as a Therapeutic Vaccine in Guinea Pigs
por: Awasthi, Sita, et al.
Publicado: (2023)

Immunogenicity, Protective Efficacy, and Non-Replicative Status of the HSV-2 Vaccine Candidate HSV529 in Mice and Guinea Pigs
por: Bernard, Marie-Clotilde, et al.
Publicado: (2015)

Correction: Effect of Copper Acyclovir Complexes on Herpes Simplex Virus Type 1 and Type 2 (HSV-1, HSV-2) Infection in Cultured Cells
por: Panteva, M., et al.
Publicado: (1998)

Intramuscular vaccination of mice with the human herpes simplex virus type-1(HSV-1) VC2 vaccine, but not its parental strain HSV-1(F) confers full protection against lethal ocular HSV-1 (McKrae) pathogenesis
por: Naidu, Shan K., et al.
Publicado: (2020)

Maternal Immunization with a Single-Cycle Herpes Simplex Virus (HSV) Candidate Vaccine, ΔgD-2, Protects Neonatal Mice from Lethal Viral Challenge
por: Kao, Carol, et al.
Publicado: (2017)

Pneumomediastinum and Pneumothorax Associated with Herpes Simplex Virus (HSV) Pneumonia
por: López-Rivera, Fermín, et al.
Publicado: (2018)

Tailoring Uptake Efficacy of HSV-1 gD Tailoring Uptake Efficacy of Hsv-1 GD Derived Carrier Peptides
por: Bősze, Szilvia, et al.
Publicado: (2020)

Disseminated Herpes Simplex Virus-2 (HSV-2) as a Cause of Viral Hepatitis in an Immunocompetent Host
por: Srinivasan, Dushyanth, et al.
Publicado: (2021)

Worldwide circulation of HSV-2 × HSV-1 recombinant strains
por: Koelle, David M., et al.
Publicado: (2017)

Antibodies to Crucial Epitopes on HSV-2 Glycoprotein D as a Guide to Dosing an mRNA Genital Herpes Vaccine
por: Hook, Lauren M., et al.
Publicado: (2022)

1410. Neonatal Herpes Simplex Virus (HSV) Infection: Is It the Only Pathogen?
por: Dendi, Alvaro, et al.
Publicado: (2020)

No Role of Herpes Simplex Virus Type 2 (HSV-2) Infection on HIV Progression in Naïve HIV Patients
por: Mohraz, Minoo, et al.
Publicado: (2018)

Negative epidemiological association between HSV-1 and HSV-2 infections
por: Nasrallah, Gheyath K., et al.
Publicado: (2019)

An HSV-2 Trivalent Vaccine Is Immunogenic in Rhesus Macaques and Highly Efficacious in Guinea Pigs
por: Awasthi, Sita, et al.
Publicado: (2017)

Microbial Diversity of Genital Ulcers of HSV-2 Seropositive Women
por: Mehta, Supriya D., et al.
Publicado: (2017)

Immunoregulatory Functions of Interferons During Genital HSV-2 Infection
por: Feng, Emily, et al.
Publicado: (2021)

Dynamics of HSV-2 infection with a therapeutic vaccine
por: Venturino, Ezio, et al.
Publicado: (2020)

Enhancement of Herpes Simplex Virus (HSV) Infection by Seminal Plasma and Semen Amyloids Implicates a New Target for the Prevention of HSV Infection
por: Torres, Lilith, et al.
Publicado: (2015)

HSV-2- and HIV-1- permissive cell lines co-infected by HSV-2 and HIV-1 co-replicate HSV-2 and HIV-1 without production of HSV-2/HIV-1 pseudotype particles
por: LeGoff, Jérôme, et al.
Publicado: (2007)

A Macaque Model to Study Vaginal HSV-2/Immunodeficiency Virus Co-Infection and the Impact of HSV-2 on Microbicide Efficacy
por: Crostarosa, Federica, et al.
Publicado: (2009)

Herpes Simplex Virus Type 2 Seroprevalence in Korea: Rapid Increase of HSV-2 Seroprevalence in the 30s in the Southern Part
por: Shin, Haeng Seop, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_c6b8fke2h9a6tbbmpcpngdj1hj