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Effect of tumor shape, size, and tissue transport properties on drug delivery to solid tumors
BACKGROUND: The computational methods provide condition for investigation related to the process of drug delivery, such as convection and diffusion of drug in extracellular matrices, drug extravasation from microvessels or to lymphatic vessels. The information of this process clarifies the mechanism...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076317/ https://www.ncbi.nlm.nih.gov/pubmed/24987457 http://dx.doi.org/10.1186/1754-1611-8-12 |
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author | Sefidgar, Mostafa Soltani, M Raahemifar, Kaamran Bazmara, Hossein Nayinian, Seyed Mojtaba Mousavi Bazargan, Majid |
author_facet | Sefidgar, Mostafa Soltani, M Raahemifar, Kaamran Bazmara, Hossein Nayinian, Seyed Mojtaba Mousavi Bazargan, Majid |
author_sort | Sefidgar, Mostafa |
collection | PubMed |
description | BACKGROUND: The computational methods provide condition for investigation related to the process of drug delivery, such as convection and diffusion of drug in extracellular matrices, drug extravasation from microvessels or to lymphatic vessels. The information of this process clarifies the mechanisms of drug delivery from the injection site to absorption by a solid tumor. In this study, an advanced numerical method is used to solve fluid flow and solute transport equations simultaneously to investigate the effect of tumor shape and size on drug delivery to solid tumor. METHODS: The advanced mathematical model used in our previous work is further developed by adding solute transport equation to the governing equations. After applying appropriate boundary and initial conditions on tumor and surrounding tissue geometry, the element-based finite volume method is used for solving governing equations of drug delivery in solid tumor. Also, the effects of size and shape of tumor and some of tissue transport parameters such as effective pressure and hydraulic conductivity on interstitial fluid flow and drug delivery are investigated. RESULTS: Sensitivity analysis shows that drug delivery in prolate shape is significantly better than other tumor shapes. Considering size effect, increasing tumor size decreases drug concentration in interstitial fluid. This study shows that dependency of drug concentration in interstitial fluid to osmotic and intravascular pressure is negligible. CONCLUSIONS: This study shows that among diffusion and convection mechanisms of drug transport, diffusion is dominant in most different tumor shapes and sizes. In tumors in which the convection has considerable effect, the drug concentration is larger than that of other tumors at the same time post injection. |
format | Online Article Text |
id | pubmed-4076317 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40763172014-07-01 Effect of tumor shape, size, and tissue transport properties on drug delivery to solid tumors Sefidgar, Mostafa Soltani, M Raahemifar, Kaamran Bazmara, Hossein Nayinian, Seyed Mojtaba Mousavi Bazargan, Majid J Biol Eng Research BACKGROUND: The computational methods provide condition for investigation related to the process of drug delivery, such as convection and diffusion of drug in extracellular matrices, drug extravasation from microvessels or to lymphatic vessels. The information of this process clarifies the mechanisms of drug delivery from the injection site to absorption by a solid tumor. In this study, an advanced numerical method is used to solve fluid flow and solute transport equations simultaneously to investigate the effect of tumor shape and size on drug delivery to solid tumor. METHODS: The advanced mathematical model used in our previous work is further developed by adding solute transport equation to the governing equations. After applying appropriate boundary and initial conditions on tumor and surrounding tissue geometry, the element-based finite volume method is used for solving governing equations of drug delivery in solid tumor. Also, the effects of size and shape of tumor and some of tissue transport parameters such as effective pressure and hydraulic conductivity on interstitial fluid flow and drug delivery are investigated. RESULTS: Sensitivity analysis shows that drug delivery in prolate shape is significantly better than other tumor shapes. Considering size effect, increasing tumor size decreases drug concentration in interstitial fluid. This study shows that dependency of drug concentration in interstitial fluid to osmotic and intravascular pressure is negligible. CONCLUSIONS: This study shows that among diffusion and convection mechanisms of drug transport, diffusion is dominant in most different tumor shapes and sizes. In tumors in which the convection has considerable effect, the drug concentration is larger than that of other tumors at the same time post injection. BioMed Central 2014-06-12 /pmc/articles/PMC4076317/ /pubmed/24987457 http://dx.doi.org/10.1186/1754-1611-8-12 Text en Copyright © 2014 Sefidgar et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Sefidgar, Mostafa Soltani, M Raahemifar, Kaamran Bazmara, Hossein Nayinian, Seyed Mojtaba Mousavi Bazargan, Majid Effect of tumor shape, size, and tissue transport properties on drug delivery to solid tumors |
title | Effect of tumor shape, size, and tissue transport properties on drug delivery to solid tumors |
title_full | Effect of tumor shape, size, and tissue transport properties on drug delivery to solid tumors |
title_fullStr | Effect of tumor shape, size, and tissue transport properties on drug delivery to solid tumors |
title_full_unstemmed | Effect of tumor shape, size, and tissue transport properties on drug delivery to solid tumors |
title_short | Effect of tumor shape, size, and tissue transport properties on drug delivery to solid tumors |
title_sort | effect of tumor shape, size, and tissue transport properties on drug delivery to solid tumors |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076317/ https://www.ncbi.nlm.nih.gov/pubmed/24987457 http://dx.doi.org/10.1186/1754-1611-8-12 |
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