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A comparative study on the effect of high cholesterol diet on the hippocampal CA1 area of adult and aged rats

Dementia is one of the most important problems nowadays. Aging is associated with learning and memory impairments. Diet rich in cholesterol has been shown to be detrimental to cognitive performance. This work was carried out to compare the effect of high cholesterol diet on the hippocampus of adult...

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Autores principales: Abo El-Khair, Doaa M., El-Safti, Fatma El-Nabawia A., Nooh, Hanaa Z., El-Mehi, Abeer E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Anatomists 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076418/
https://www.ncbi.nlm.nih.gov/pubmed/24987548
http://dx.doi.org/10.5115/acb.2014.47.2.117
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author Abo El-Khair, Doaa M.
El-Safti, Fatma El-Nabawia A.
Nooh, Hanaa Z.
El-Mehi, Abeer E.
author_facet Abo El-Khair, Doaa M.
El-Safti, Fatma El-Nabawia A.
Nooh, Hanaa Z.
El-Mehi, Abeer E.
author_sort Abo El-Khair, Doaa M.
collection PubMed
description Dementia is one of the most important problems nowadays. Aging is associated with learning and memory impairments. Diet rich in cholesterol has been shown to be detrimental to cognitive performance. This work was carried out to compare the effect of high cholesterol diet on the hippocampus of adult and aged male albino rats. Twenty adult and twenty aged male rats were used in this study. According to age, the rats were randomly subdivided into balanced and high cholesterol diet fed groups. The diet was 15 g/rat/day for adult rats and 20 g/rat/day for aged rats for eight weeks. Serial coronal sections of hippocampus and blood samples were taken from each rat. For diet effect evaluation, Clinical, biochemical, histological, immunohistochemical, and morphometric assessments were done. In compare to a balanced diet fed rat, examination of Cornu Ammonis 1 (CA 1) area in the hippocampus of the high cholesterol diet adult rats showed degeneration, a significant decrease of the pyramidal cells, attenuation and/or thickening of small blood vessels, apparent increase of astrocytes and apparent decrease of Nissl's granules content. Moreover, the high cholesterol diet aged rats showed aggravation of senility changes of the hippocampus together with Alzheimer like pathological changes. In conclusion, the high cholesterol diet has a significant detrimental effect on the hippocampus and aging might pronounce this effect. So, we should direct our attention to limit cholesterol intake in our food to maintain a healthy life style for a successful aging.
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spelling pubmed-40764182014-07-01 A comparative study on the effect of high cholesterol diet on the hippocampal CA1 area of adult and aged rats Abo El-Khair, Doaa M. El-Safti, Fatma El-Nabawia A. Nooh, Hanaa Z. El-Mehi, Abeer E. Anat Cell Biol Original Article Dementia is one of the most important problems nowadays. Aging is associated with learning and memory impairments. Diet rich in cholesterol has been shown to be detrimental to cognitive performance. This work was carried out to compare the effect of high cholesterol diet on the hippocampus of adult and aged male albino rats. Twenty adult and twenty aged male rats were used in this study. According to age, the rats were randomly subdivided into balanced and high cholesterol diet fed groups. The diet was 15 g/rat/day for adult rats and 20 g/rat/day for aged rats for eight weeks. Serial coronal sections of hippocampus and blood samples were taken from each rat. For diet effect evaluation, Clinical, biochemical, histological, immunohistochemical, and morphometric assessments were done. In compare to a balanced diet fed rat, examination of Cornu Ammonis 1 (CA 1) area in the hippocampus of the high cholesterol diet adult rats showed degeneration, a significant decrease of the pyramidal cells, attenuation and/or thickening of small blood vessels, apparent increase of astrocytes and apparent decrease of Nissl's granules content. Moreover, the high cholesterol diet aged rats showed aggravation of senility changes of the hippocampus together with Alzheimer like pathological changes. In conclusion, the high cholesterol diet has a significant detrimental effect on the hippocampus and aging might pronounce this effect. So, we should direct our attention to limit cholesterol intake in our food to maintain a healthy life style for a successful aging. Korean Association of Anatomists 2014-06 2014-06-20 /pmc/articles/PMC4076418/ /pubmed/24987548 http://dx.doi.org/10.5115/acb.2014.47.2.117 Text en Copyright © 2014. Anatomy & Cell Biology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Abo El-Khair, Doaa M.
El-Safti, Fatma El-Nabawia A.
Nooh, Hanaa Z.
El-Mehi, Abeer E.
A comparative study on the effect of high cholesterol diet on the hippocampal CA1 area of adult and aged rats
title A comparative study on the effect of high cholesterol diet on the hippocampal CA1 area of adult and aged rats
title_full A comparative study on the effect of high cholesterol diet on the hippocampal CA1 area of adult and aged rats
title_fullStr A comparative study on the effect of high cholesterol diet on the hippocampal CA1 area of adult and aged rats
title_full_unstemmed A comparative study on the effect of high cholesterol diet on the hippocampal CA1 area of adult and aged rats
title_short A comparative study on the effect of high cholesterol diet on the hippocampal CA1 area of adult and aged rats
title_sort comparative study on the effect of high cholesterol diet on the hippocampal ca1 area of adult and aged rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076418/
https://www.ncbi.nlm.nih.gov/pubmed/24987548
http://dx.doi.org/10.5115/acb.2014.47.2.117
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