Cargando…

FK506 reduces calpain-regulated calcineurin activity in both the cytoplasm and the nucleus

Excessive immune responses induced by ischemia-reperfusion injury (IRI) are known to lead to necrotic and apoptotic cell death, and calcineurin plays a major role in this process. Calcineurin dephosphorylates the nuclear factor of activated T-cells (NFAT), permitting its translocation into the nucle...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Sun Hee, Choi, Jungil, Kim, Hwajin, Lee, Dong Hoon, Roh, Gu Seob, Kim, Hyun Joon, Kang, Sang Soo, Choi, Wan Sung, Cho, Gyeong Jae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Association of Anatomists 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076426/ https://www.ncbi.nlm.nih.gov/pubmed/24987545 http://dx.doi.org/10.5115/acb.2014.47.2.91

Ejemplares similares

The Effect of FK 506 on the Reepithelialization of Superficial Skin Wound
por: Shin, Jeong Min, et al.
Publicado: (2017)

Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?
por: Sieber, Matthias, et al.
Publicado: (2009)

Treatment With Calcineurin Inhibitor FK506 Attenuates Noise-Induced Hearing Loss
por: He, Zu-Hong, et al.
Publicado: (2021)

Interactions of FK506 and Rapamycin With FK506 Binding Protein 12 in Opportunistic Human Fungal Pathogens
por: Vellanki, Sandeep, et al.
Publicado: (2020)

Physosmotic Induction of Chondrogenic Maturation Is TGF-β Dependent and Enhanced by Calcineurin Inhibitor FK506
por: Jahr, Holger, et al.
Publicado: (2022)

Maculopathy Associated with Tacrolimus (FK 506)
por: Koh, Taehyuk, et al.
Publicado: (2011)

Inhibition of calcineurin by FK506 stimulates germinal vesicle breakdown of mouse oocytes in hypoxanthine-supplemented medium
por: Wang, Li, et al.
Publicado: (2017)

Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents
por: Juvvadi, Praveen R., et al.
Publicado: (2019)

Pathogenic virus-specific T cells cause disease during treatment with the calcineurin inhibitor FK506: implications for transplantation
por: Araki, Koichi, et al.
Publicado: (2010)

FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury
por: Lee, Bohm, et al.
Publicado: (2022)

The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin
Publicado: (1992)

FK506 immunosuppression for submandibular salivary gland allotransplantation in rabbit
por: Almansoori, Akram Abdo, et al.
Publicado: (2020)

Effects of PEP-1-FK506BP on cyst formation in polycystic kidney disease
por: Jo, Hyo Sang, et al.
Publicado: (2017)

The Calcineurin Inhibitor FK506 Prevents Cognitive Impairment by Inhibiting Reactive Astrogliosis in Pilocarpine-Induced Status Epilepticus Rats
por: Liu, Jinzhi, et al.
Publicado: (2018)

Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs
por: Gobeil, Sophie M.-C., et al.
Publicado: (2021)

The effects of PEP-1-FK506BP on dry eye disease in a rat model
por: Kim, Dae Won, et al.
Publicado: (2015)

FK506 Induces the TGF-β1/Smad 3 Pathway Independently of Calcineurin Inhibition to Prevent Intervertebral Disk Degeneration
por: Ge, Jun, et al.
Publicado: (2020)

Development of Non-Immunosuppressive FK506 Derivatives as Antifungal and Neurotrophic Agents
por: Jung, Jin A, et al.
Publicado: (2020)

Effects of FK506 on Ca(2+) Release Channels (Review)
por: Ozawa, Terutaka
Publicado: (2008)

Molecular Evolution of the Vertebrate FK506 Binding Protein 25
por: Liu, Fei, et al.
Publicado: (2014)

FK506 attenuates thymic output in patients with myasthenia gravis
por: Mitsui, Takao, et al.
Publicado: (2013)

Role of FK506-sensitive signals in asthmatic lung inflammation
por: Tomiaki, Chihiro, et al.
Publicado: (2022)

FK506-Binding Protein 2 Participates in Proinsulin Folding
por: Hoefner, Carolin, et al.
Publicado: (2023)

49. Recruited Macrophages are Required for Neuroenhancing Effects of Fk506
por: Broberg, Curtis, et al.
Publicado: (2023)

Advancing Nerve Regeneration: Translational Perspectives of Tacrolimus (FK506)
por: Daeschler, Simeon C., et al.
Publicado: (2023)

Effects of immunosuppressants, FK506 and cyclosporin A, on the osteogenic differentiation of rat mesenchymal stem cells
por: Byun, Yu-Kyung, et al.
Publicado: (2012)

PEP-1-FK506BP inhibits alkali burn-induced corneal inflammation on the rat model of corneal alkali injury
por: Kim, Dae Won, et al.
Publicado: (2015)

Fenobam promoted the neuroprotective effect of PEP-1-FK506BP following oxidative stress by increasing its transduction efficiency
por: Ahn, Eun Hee, et al.
Publicado: (2013)

An improved reversibly dimerizing mutant of the FK506-binding protein FKBP
por: Barrero, Juan J., et al.
Publicado: (2016)

Abstract 134: FK506 Delivering Conduit For Peripheral Nerve Regeneration
por: Labroo, Pratima, et al.
Publicado: (2017)

Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35
por: Atack, Thomas C., et al.
Publicado: (2020)

FK506 Attenuated Pilocarpine-Induced Epilepsy by Reducing Inflammation in Rats
por: Wang, Aihua, et al.
Publicado: (2019)

FK506 increases susceptibility to musculoskeletal infection in a rodent model
por: Shiels, Stefanie M., et al.
Publicado: (2022)

Optimization of the precursor supply for an enhanced FK506 production in Streptomyces tsukubaensis
por: Schulz, Susann, et al.
Publicado: (2022)

Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus
por: Hoy, Michael J., et al.
Publicado: (2022)

Protective effect of Korean Red Ginseng against FK506-induced damage in LLC-PK1 cells
por: Lee, Dahae, et al.
Publicado: (2017)

Early steps of microglial activation are directly affected by neuroprotectant FK506 in both in vitro inflammation and in rat model of stroke
por: Zawadzka, Malgorzata, et al.
Publicado: (2012)

Transduced PEP-1-FK506BP ameliorates corneal injury in Botulinum toxin A-induced dry eye mouse model
por: Kim, Dae Won, et al.
Publicado: (2013)

FK506 and Lactobacillus acidophilus ameliorate acute graft-versus-host disease by modulating the T helper 17/regulatory T-cell balance
por: Beak, Jin-Ah, et al.
Publicado: (2022)

FK506-binding protein 51 is a possible novel tumoral marker
por: Romano, S, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_a5uiq07n3gcp8kmhhi2j9867mp