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Quantitative quadruple-label immunofluorescence of mitochondrial and cytoplasmic proteins in single neurons from human midbrain tissue

BACKGROUND: Respiratory chain (RC) deficiencies are found in primary mtDNA diseases. Focal RC defects are also associated with ageing and neurodegenerative disorders, e.g. in substantia nigra (SN) neurons from Parkinson's disease patients. In mitochondrial disease and ageing, mtDNA mutational l...

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Detalles Bibliográficos
Autores principales:	Grünewald, Anne, Lax, Nichola Z., Rocha, Mariana C., Reeve, Amy K., Hepplewhite, Philippa D., A. Rygiel, Karolina, Taylor, Robert W., Turnbull, Doug M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier/North-Holland Biomedical Press 2014
Materias:	Basic Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076514/ https://www.ncbi.nlm.nih.gov/pubmed/24880043 http://dx.doi.org/10.1016/j.jneumeth.2014.05.026

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