Epidermal growth factor-receptor activation modulates Src-dependent resistance to lapatinib in breast cancer models

INTRODUCTION: Src tyrosine kinase overactivation has been correlated with a poor response to human epidermal growth factor receptor 2 (HER2) inhibitors in breast cancer. To identify the mechanism by which Src overexpression sustains this resistance, we tested a panel of breast cancer cell lines eith...

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Detalles Bibliográficos
Autores principales: Formisano, Luigi, Nappi, Lucia, Rosa, Roberta, Marciano, Roberta, D’Amato, Claudia, D’Amato, Valentina, Damiano, Vincenzo, Raimondo, Lucia, Iommelli, Francesca, Scorziello, Antonella, Troncone, Giancarlo, Veneziani, Bianca Maria, Parsons, Sarah J, De Placido, Sabino, Bianco, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076622/
https://www.ncbi.nlm.nih.gov/pubmed/24887236
http://dx.doi.org/10.1186/bcr3650

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