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Electroencephalographic effects of ketamine on power, cross-frequency coupling, and connectivity in the alpha bandwidth
Recent studies of propofol-induced unconsciousness have identified characteristic properties of electroencephalographic alpha rhythms that may be mediated by drug activity at γ-aminobutyric acid (GABA) receptors in the thalamus. However, the effect of ketamine (a primarily non-GABAergic anesthetic d...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076669/ https://www.ncbi.nlm.nih.gov/pubmed/25071473 http://dx.doi.org/10.3389/fnsys.2014.00114 |
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author | Blain-Moraes, Stefanie Lee, UnCheol Ku, SeungWoo Noh, GyuJeong Mashour, George A. |
author_facet | Blain-Moraes, Stefanie Lee, UnCheol Ku, SeungWoo Noh, GyuJeong Mashour, George A. |
author_sort | Blain-Moraes, Stefanie |
collection | PubMed |
description | Recent studies of propofol-induced unconsciousness have identified characteristic properties of electroencephalographic alpha rhythms that may be mediated by drug activity at γ-aminobutyric acid (GABA) receptors in the thalamus. However, the effect of ketamine (a primarily non-GABAergic anesthetic drug) on alpha oscillations has not been systematically evaluated. We analyzed the electroencephalogram of 28 surgical patients during consciousness and ketamine-induced unconsciousness with a focus on frontal power, frontal cross-frequency coupling, frontal-parietal functional connectivity (measured by coherence and phase lag index), and frontal-to-parietal directional connectivity (measured by directed phase lag index) in the alpha bandwidth. Unlike past studies of propofol, ketamine-induced unconsciousness was not associated with increases in the power of frontal alpha rhythms, characteristic cross-frequency coupling patterns of frontal alpha power and slow-oscillation phase, or decreases in coherence in the alpha bandwidth. Like past studies of propofol using undirected and directed phase lag index, ketamine reduced frontal-parietal (functional) and frontal-to-parietal (directional) connectivity in the alpha bandwidth. These results suggest that directional connectivity changes in the alpha bandwidth may be state-related markers of unconsciousness induced by both GABAergic and non-GABAergic anesthetics. |
format | Online Article Text |
id | pubmed-4076669 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-40766692014-07-28 Electroencephalographic effects of ketamine on power, cross-frequency coupling, and connectivity in the alpha bandwidth Blain-Moraes, Stefanie Lee, UnCheol Ku, SeungWoo Noh, GyuJeong Mashour, George A. Front Syst Neurosci Neuroscience Recent studies of propofol-induced unconsciousness have identified characteristic properties of electroencephalographic alpha rhythms that may be mediated by drug activity at γ-aminobutyric acid (GABA) receptors in the thalamus. However, the effect of ketamine (a primarily non-GABAergic anesthetic drug) on alpha oscillations has not been systematically evaluated. We analyzed the electroencephalogram of 28 surgical patients during consciousness and ketamine-induced unconsciousness with a focus on frontal power, frontal cross-frequency coupling, frontal-parietal functional connectivity (measured by coherence and phase lag index), and frontal-to-parietal directional connectivity (measured by directed phase lag index) in the alpha bandwidth. Unlike past studies of propofol, ketamine-induced unconsciousness was not associated with increases in the power of frontal alpha rhythms, characteristic cross-frequency coupling patterns of frontal alpha power and slow-oscillation phase, or decreases in coherence in the alpha bandwidth. Like past studies of propofol using undirected and directed phase lag index, ketamine reduced frontal-parietal (functional) and frontal-to-parietal (directional) connectivity in the alpha bandwidth. These results suggest that directional connectivity changes in the alpha bandwidth may be state-related markers of unconsciousness induced by both GABAergic and non-GABAergic anesthetics. Frontiers Media S.A. 2014-07-01 /pmc/articles/PMC4076669/ /pubmed/25071473 http://dx.doi.org/10.3389/fnsys.2014.00114 Text en Copyright © 2014 Blain-Moraes, Lee, Ku, Noh and Mashour. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Blain-Moraes, Stefanie Lee, UnCheol Ku, SeungWoo Noh, GyuJeong Mashour, George A. Electroencephalographic effects of ketamine on power, cross-frequency coupling, and connectivity in the alpha bandwidth |
title | Electroencephalographic effects of ketamine on power, cross-frequency coupling, and connectivity in the alpha bandwidth |
title_full | Electroencephalographic effects of ketamine on power, cross-frequency coupling, and connectivity in the alpha bandwidth |
title_fullStr | Electroencephalographic effects of ketamine on power, cross-frequency coupling, and connectivity in the alpha bandwidth |
title_full_unstemmed | Electroencephalographic effects of ketamine on power, cross-frequency coupling, and connectivity in the alpha bandwidth |
title_short | Electroencephalographic effects of ketamine on power, cross-frequency coupling, and connectivity in the alpha bandwidth |
title_sort | electroencephalographic effects of ketamine on power, cross-frequency coupling, and connectivity in the alpha bandwidth |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076669/ https://www.ncbi.nlm.nih.gov/pubmed/25071473 http://dx.doi.org/10.3389/fnsys.2014.00114 |
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