An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E(-/-) mice

Oxidized low-density lipoprotein (oxLDL) inhibits mammalian target of rapamycin (mTOR) and induces autophagy and apoptosis in vascular endothelial cells (VECs) that play very critical roles for the cardiovascular homostasis. We recently defined 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)...

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Detalles Bibliográficos
Autores principales: Peng, Nan, Meng, Ning, Wang, ShengQing, Zhao, Fei, Zhao, Jing, Su, Le, Zhang, ShangLi, Zhang, Yun, Zhao, BaoXiang, Miao, JunYing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076681/
https://www.ncbi.nlm.nih.gov/pubmed/24980430
http://dx.doi.org/10.1038/srep05519

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