Phenotypic Characteristics of Diabetic Kidney Involvement

Understanding phenotypic characteristics of the diabetic kidney is important to developing therapies to prevent progression of diabetic nephropathy. In addition to glomerular hyperfiltration and kidney growth, major metabolic abnormalities characterize the diabetic kidney. Increased kidney oxygen co...

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Detalles Bibliográficos
Autor principal: Blantz, Roland C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076684/
https://www.ncbi.nlm.nih.gov/pubmed/24978373
http://dx.doi.org/10.1038/ki.2013.552
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author Blantz, Roland C.
author_facet Blantz, Roland C.
author_sort Blantz, Roland C.
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description Understanding phenotypic characteristics of the diabetic kidney is important to developing therapies to prevent progression of diabetic nephropathy. In addition to glomerular hyperfiltration and kidney growth, major metabolic abnormalities characterize the diabetic kidney. Increased kidney oxygen consumption leads to cortical and medullary hypoxia in diabetes. Decreasing inspired oxygen to 10% reduces pO(2) while oxygen consumption remains elevated while lactate increases and the redox potential decreases but only in diabetic kidney, a shift to Warburg metabolism.
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spelling pubmed-40766842015-01-01 Phenotypic Characteristics of Diabetic Kidney Involvement Blantz, Roland C. Kidney Int Article Understanding phenotypic characteristics of the diabetic kidney is important to developing therapies to prevent progression of diabetic nephropathy. In addition to glomerular hyperfiltration and kidney growth, major metabolic abnormalities characterize the diabetic kidney. Increased kidney oxygen consumption leads to cortical and medullary hypoxia in diabetes. Decreasing inspired oxygen to 10% reduces pO(2) while oxygen consumption remains elevated while lactate increases and the redox potential decreases but only in diabetic kidney, a shift to Warburg metabolism. 2014-07 /pmc/articles/PMC4076684/ /pubmed/24978373 http://dx.doi.org/10.1038/ki.2013.552 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Blantz, Roland C.
Phenotypic Characteristics of Diabetic Kidney Involvement
title Phenotypic Characteristics of Diabetic Kidney Involvement
title_full Phenotypic Characteristics of Diabetic Kidney Involvement
title_fullStr Phenotypic Characteristics of Diabetic Kidney Involvement
title_full_unstemmed Phenotypic Characteristics of Diabetic Kidney Involvement
title_short Phenotypic Characteristics of Diabetic Kidney Involvement
title_sort phenotypic characteristics of diabetic kidney involvement
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076684/
https://www.ncbi.nlm.nih.gov/pubmed/24978373
http://dx.doi.org/10.1038/ki.2013.552
work_keys_str_mv AT blantzrolandc phenotypiccharacteristicsofdiabetickidneyinvolvement

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