The effect of pseudocatalase/superoxide dismutase in the treatment of vitiligo: A pilot study

OBJECTIVE: Pseudocatalase/superoxide dismutase (PSD) is a topical gel considered having therapeutic effects in vitiligo. This study was designed to evaluate the efficacy of this combination in vitiligo. METHODS: This was a pilot randomized, double-blind, placebo-controlled trial on 46 symmetrical vi...

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Autores principales: Naini, Farahnaz Fatemi, Shooshtari, Alireza Vaez, Ebrahimi, Bahareh, Molaei, Razieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076862/
https://www.ncbi.nlm.nih.gov/pubmed/24991594
http://dx.doi.org/10.4103/2279-042X.108375
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author Naini, Farahnaz Fatemi
Shooshtari, Alireza Vaez
Ebrahimi, Bahareh
Molaei, Razieh
author_facet Naini, Farahnaz Fatemi
Shooshtari, Alireza Vaez
Ebrahimi, Bahareh
Molaei, Razieh
author_sort Naini, Farahnaz Fatemi
collection PubMed
description OBJECTIVE: Pseudocatalase/superoxide dismutase (PSD) is a topical gel considered having therapeutic effects in vitiligo. This study was designed to evaluate the efficacy of this combination in vitiligo. METHODS: This was a pilot randomized, double-blind, placebo-controlled trial on 46 symmetrical vitiligo lesions of limbs in 23 patients referring to dermatology clinics, Isfahan, Iran in 2010. Patients were received this formula or placebo gels for the right and left lesions. Lesion area and degree of pigmentation were assessed at baseline, 2, 4, and 6 months. FINDINGS: There were no significant changes in lesion area and perifollicular pigmentation in each group (P > 0.05). CONCLUSION: The results indicated no significant therapeutic effect for PSD in vitiligo.
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spelling pubmed-40768622014-07-02 The effect of pseudocatalase/superoxide dismutase in the treatment of vitiligo: A pilot study Naini, Farahnaz Fatemi Shooshtari, Alireza Vaez Ebrahimi, Bahareh Molaei, Razieh J Res Pharm Pract Brief Communication OBJECTIVE: Pseudocatalase/superoxide dismutase (PSD) is a topical gel considered having therapeutic effects in vitiligo. This study was designed to evaluate the efficacy of this combination in vitiligo. METHODS: This was a pilot randomized, double-blind, placebo-controlled trial on 46 symmetrical vitiligo lesions of limbs in 23 patients referring to dermatology clinics, Isfahan, Iran in 2010. Patients were received this formula or placebo gels for the right and left lesions. Lesion area and degree of pigmentation were assessed at baseline, 2, 4, and 6 months. FINDINGS: There were no significant changes in lesion area and perifollicular pigmentation in each group (P > 0.05). CONCLUSION: The results indicated no significant therapeutic effect for PSD in vitiligo. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC4076862/ /pubmed/24991594 http://dx.doi.org/10.4103/2279-042X.108375 Text en Copyright: © Journal of Research in Pharmacy Practice http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Naini, Farahnaz Fatemi
Shooshtari, Alireza Vaez
Ebrahimi, Bahareh
Molaei, Razieh
The effect of pseudocatalase/superoxide dismutase in the treatment of vitiligo: A pilot study
title The effect of pseudocatalase/superoxide dismutase in the treatment of vitiligo: A pilot study
title_full The effect of pseudocatalase/superoxide dismutase in the treatment of vitiligo: A pilot study
title_fullStr The effect of pseudocatalase/superoxide dismutase in the treatment of vitiligo: A pilot study
title_full_unstemmed The effect of pseudocatalase/superoxide dismutase in the treatment of vitiligo: A pilot study
title_short The effect of pseudocatalase/superoxide dismutase in the treatment of vitiligo: A pilot study
title_sort effect of pseudocatalase/superoxide dismutase in the treatment of vitiligo: a pilot study
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076862/
https://www.ncbi.nlm.nih.gov/pubmed/24991594
http://dx.doi.org/10.4103/2279-042X.108375
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