Cargando…
TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes
Chromosomal instability can arise from defects in chromosome–microtubule attachment. Using a variety of drug treatments, we show that TAO1 kinase is required for ensuring the normal congression of chromosomes. Depletion of TAO1 reduces the density of growing interphase and mitotic microtubules in hu...
Autores principales: | Shrestha, Roshan L., Tamura, Naoka, Fries, Anna, Levin, Nicolas, Clark, Joanna, Draviam, Viji M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077056/ https://www.ncbi.nlm.nih.gov/pubmed/24898139 http://dx.doi.org/10.1098/rsob.130108 |
Ejemplares similares
-
Lateral to End-on Conversion of Chromosome-Microtubule Attachment Requires Kinesins CENP-E and MCAK
por: Shrestha, Roshan L., et al.
Publicado: (2013) -
Lateral to End-on Conversion of Chromosome-Microtubule Attachment Requires Kinesins CENP-E and MCAK
por: Shrestha, Roshan L., et al.
Publicado: (2013) -
Microtubule plus-ends within a mitotic cell are ‘moving platforms’ with anchoring, signalling and force-coupling roles
por: Tamura, Naoka, et al.
Publicado: (2012) -
Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells
por: Shrestha, Roshan L., et al.
Publicado: (2017) -
Kinetochores attached to microtubule-ends are stabilised by Astrin bound PP1 to ensure proper chromosome segregation
por: Conti, Duccio, et al.
Publicado: (2019)