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Long term cerebral and vascular complications after irradiation of the neck in head and neck cancer patients: a prospective cohort study: study rationale and protocol

BACKGROUND: Successful treatment options for cancer result in more young long-term survivors prone for long-term complications. Carotid artery vasculopathy is a potential long-term complication after radiotherapy of the neck, resulting in cerebrovascular events and probably deficits in cognitive and...

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Autores principales: Wilbers, Joyce, Kappelle, Arnoud C, Kessels, Roy PC, Steens, Stefan CA, Meijer, Frederick JA, Kaanders, Johannes H, Haast, Roy AM, Versteeg, Laura E, Tuladhar, Anil M, de Korte, Chris L, Hansen, Hendrik HG, Hoebers, Frank J, Boogerd, Willem, van Werkhoven, Erik D, Nowee, Marlies E, Hart, Guus, Bartelink, Harry, Dorresteijn, Lucille D, van Dijk, Ewoud J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077148/
https://www.ncbi.nlm.nih.gov/pubmed/24942263
http://dx.doi.org/10.1186/1471-2377-14-132
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author Wilbers, Joyce
Kappelle, Arnoud C
Kessels, Roy PC
Steens, Stefan CA
Meijer, Frederick JA
Kaanders, Johannes H
Haast, Roy AM
Versteeg, Laura E
Tuladhar, Anil M
de Korte, Chris L
Hansen, Hendrik HG
Hoebers, Frank J
Boogerd, Willem
van Werkhoven, Erik D
Nowee, Marlies E
Hart, Guus
Bartelink, Harry
Dorresteijn, Lucille D
van Dijk, Ewoud J
author_facet Wilbers, Joyce
Kappelle, Arnoud C
Kessels, Roy PC
Steens, Stefan CA
Meijer, Frederick JA
Kaanders, Johannes H
Haast, Roy AM
Versteeg, Laura E
Tuladhar, Anil M
de Korte, Chris L
Hansen, Hendrik HG
Hoebers, Frank J
Boogerd, Willem
van Werkhoven, Erik D
Nowee, Marlies E
Hart, Guus
Bartelink, Harry
Dorresteijn, Lucille D
van Dijk, Ewoud J
author_sort Wilbers, Joyce
collection PubMed
description BACKGROUND: Successful treatment options for cancer result in more young long-term survivors prone for long-term complications. Carotid artery vasculopathy is a potential long-term complication after radiotherapy of the neck, resulting in cerebrovascular events and probably deficits in cognitive and motor functioning. Better insight into the underlying pathofysiology of radiotherapy induced carotid artery vasculopathy is needed for prognostic purposes and to develop preventive strategies. METHODS/DESIGN: The current study is a prospective cohort study on the long-term cerebral and vascular complications after radiotherapy of the neck, in 103 patients treated for head and neck cancer, included in our study database between 2002 and 2008. Baseline protocol (before radiotherapy) included screening for cerebrovascular risk factors and intima media thickness measurement of carotid arteries by ultrasonography. Follow-up assessment more than 5 years after radiotherapy included screening of cerebrovascular risk factors, cerebrovascular events, neurological examination with gait and balance tests, extensive neuropsychological examination, self-report questionnaires, ultrasonography of the carotid arteries with measurement of intima media thickness and elastography, magnetic resonance imaging of the brain and magnetic resonance angiography of the carotid arteries. DISCUSSION: The current study adds to the understanding of the causes and consequences of long-term cerebral and vascular changes after radiotherapy of the neck. These data will be helpful to develop a protocol for diagnostic and preventive strategies for long-term neurological complications in future head and neck cancer patients with anticipated radiotherapy treatment.
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spelling pubmed-40771482014-07-02 Long term cerebral and vascular complications after irradiation of the neck in head and neck cancer patients: a prospective cohort study: study rationale and protocol Wilbers, Joyce Kappelle, Arnoud C Kessels, Roy PC Steens, Stefan CA Meijer, Frederick JA Kaanders, Johannes H Haast, Roy AM Versteeg, Laura E Tuladhar, Anil M de Korte, Chris L Hansen, Hendrik HG Hoebers, Frank J Boogerd, Willem van Werkhoven, Erik D Nowee, Marlies E Hart, Guus Bartelink, Harry Dorresteijn, Lucille D van Dijk, Ewoud J BMC Neurol Study Protocol BACKGROUND: Successful treatment options for cancer result in more young long-term survivors prone for long-term complications. Carotid artery vasculopathy is a potential long-term complication after radiotherapy of the neck, resulting in cerebrovascular events and probably deficits in cognitive and motor functioning. Better insight into the underlying pathofysiology of radiotherapy induced carotid artery vasculopathy is needed for prognostic purposes and to develop preventive strategies. METHODS/DESIGN: The current study is a prospective cohort study on the long-term cerebral and vascular complications after radiotherapy of the neck, in 103 patients treated for head and neck cancer, included in our study database between 2002 and 2008. Baseline protocol (before radiotherapy) included screening for cerebrovascular risk factors and intima media thickness measurement of carotid arteries by ultrasonography. Follow-up assessment more than 5 years after radiotherapy included screening of cerebrovascular risk factors, cerebrovascular events, neurological examination with gait and balance tests, extensive neuropsychological examination, self-report questionnaires, ultrasonography of the carotid arteries with measurement of intima media thickness and elastography, magnetic resonance imaging of the brain and magnetic resonance angiography of the carotid arteries. DISCUSSION: The current study adds to the understanding of the causes and consequences of long-term cerebral and vascular changes after radiotherapy of the neck. These data will be helpful to develop a protocol for diagnostic and preventive strategies for long-term neurological complications in future head and neck cancer patients with anticipated radiotherapy treatment. BioMed Central 2014-06-19 /pmc/articles/PMC4077148/ /pubmed/24942263 http://dx.doi.org/10.1186/1471-2377-14-132 Text en Copyright © 2014 Wilbers et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Study Protocol
Wilbers, Joyce
Kappelle, Arnoud C
Kessels, Roy PC
Steens, Stefan CA
Meijer, Frederick JA
Kaanders, Johannes H
Haast, Roy AM
Versteeg, Laura E
Tuladhar, Anil M
de Korte, Chris L
Hansen, Hendrik HG
Hoebers, Frank J
Boogerd, Willem
van Werkhoven, Erik D
Nowee, Marlies E
Hart, Guus
Bartelink, Harry
Dorresteijn, Lucille D
van Dijk, Ewoud J
Long term cerebral and vascular complications after irradiation of the neck in head and neck cancer patients: a prospective cohort study: study rationale and protocol
title Long term cerebral and vascular complications after irradiation of the neck in head and neck cancer patients: a prospective cohort study: study rationale and protocol
title_full Long term cerebral and vascular complications after irradiation of the neck in head and neck cancer patients: a prospective cohort study: study rationale and protocol
title_fullStr Long term cerebral and vascular complications after irradiation of the neck in head and neck cancer patients: a prospective cohort study: study rationale and protocol
title_full_unstemmed Long term cerebral and vascular complications after irradiation of the neck in head and neck cancer patients: a prospective cohort study: study rationale and protocol
title_short Long term cerebral and vascular complications after irradiation of the neck in head and neck cancer patients: a prospective cohort study: study rationale and protocol
title_sort long term cerebral and vascular complications after irradiation of the neck in head and neck cancer patients: a prospective cohort study: study rationale and protocol
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077148/
https://www.ncbi.nlm.nih.gov/pubmed/24942263
http://dx.doi.org/10.1186/1471-2377-14-132
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