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Development and antitumor activity of a BCL-2 targeted single-stranded DNA oligonucleotide

PNT100 is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to a region upstream of the BCL-2 gene. Exposure of tumor cells to PNT100 results in suppression of proliferation and cell death by a process called DNA interference. PNT2258 is PNT100 that is encapsulated...

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Detalles Bibliográficos
Autores principales:	Rodrigueza, Wendi V., Woolliscroft, Michael J., Ebrahim, Abdul-Shukkur, Forgey, Robert, McGovren, Patrick J., Endert, Gerold, Wagner, Andreas, Holewa, Danielle, Aboukameel, Amro, Gill, Richard D., Bisgaier, Charles L., Messmann, Richard A., Whitehead, Christopher E., Izbicka, Elzbieta, Streeper, Robert, Wick, Michael C., Stiegler, Gabriela, Stein, C. A., Monsma, David, Webb, Craig, Sooch, Mina P., Panzner, Steffen, Mohammad, Ramzi, Goodwin, Neal C., Al-Katib, Ayad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077254/ https://www.ncbi.nlm.nih.gov/pubmed/24832107 http://dx.doi.org/10.1007/s00280-014-2476-y

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