Syntheses of fluorooxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester

Diethyl 2-fluoromalonate ester is utilised as a building block for the synthesis of 2-fluoro-2-arylacetic acid and fluorooxindole derivatives by a strategy involving nucleophilic aromatic substitution reactions with ortho-fluoronitrobenzene substrates followed by decarboxylation, esterification and...

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Autores principales: Harsanyi, Antal, Sandford, Graham, Yufit, Dmitri S, Howard, Judith AK
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077372/
https://www.ncbi.nlm.nih.gov/pubmed/24991270
http://dx.doi.org/10.3762/bjoc.10.119
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author Harsanyi, Antal
Sandford, Graham
Yufit, Dmitri S
Howard, Judith AK
author_facet Harsanyi, Antal
Sandford, Graham
Yufit, Dmitri S
Howard, Judith AK
author_sort Harsanyi, Antal
collection PubMed
description Diethyl 2-fluoromalonate ester is utilised as a building block for the synthesis of 2-fluoro-2-arylacetic acid and fluorooxindole derivatives by a strategy involving nucleophilic aromatic substitution reactions with ortho-fluoronitrobenzene substrates followed by decarboxylation, esterification and reductive cyclisation processes.
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spelling pubmed-40773722014-07-02 Syntheses of fluorooxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester Harsanyi, Antal Sandford, Graham Yufit, Dmitri S Howard, Judith AK Beilstein J Org Chem Full Research Paper Diethyl 2-fluoromalonate ester is utilised as a building block for the synthesis of 2-fluoro-2-arylacetic acid and fluorooxindole derivatives by a strategy involving nucleophilic aromatic substitution reactions with ortho-fluoronitrobenzene substrates followed by decarboxylation, esterification and reductive cyclisation processes. Beilstein-Institut 2014-05-22 /pmc/articles/PMC4077372/ /pubmed/24991270 http://dx.doi.org/10.3762/bjoc.10.119 Text en Copyright © 2014, Harsanyi et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Harsanyi, Antal
Sandford, Graham
Yufit, Dmitri S
Howard, Judith AK
Syntheses of fluorooxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester
title Syntheses of fluorooxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester
title_full Syntheses of fluorooxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester
title_fullStr Syntheses of fluorooxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester
title_full_unstemmed Syntheses of fluorooxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester
title_short Syntheses of fluorooxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester
title_sort syntheses of fluorooxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077372/
https://www.ncbi.nlm.nih.gov/pubmed/24991270
http://dx.doi.org/10.3762/bjoc.10.119
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