Cargando…

Automated solid-phase peptide synthesis to obtain therapeutic peptides

The great versatility and the inherent high affinities of peptides for their respective targets have led to tremendous progress for therapeutic applications in the last years. In order to increase the drugability of these frequently unstable and rapidly cleared molecules, chemical modifications are...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mäde, Veronika, Els-Heindl, Sylvia, Beck-Sickinger, Annette G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2014
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077397/ https://www.ncbi.nlm.nih.gov/pubmed/24991269 http://dx.doi.org/10.3762/bjoc.10.118

Ejemplares similares

Peptide-Drug Conjugates and Their Targets in Advanced Cancer Therapies
por: Hoppenz, Paul, et al.
Publicado: (2020)

RFamide Peptides: Structure, Function, Mechanisms and Pharmaceutical Potential
por: Findeisen, Maria, et al.
Publicado: (2011)

Development of Fluorinated Non-Peptidic Ghrelin Receptor Ligands for Potential Use in Molecular Imaging
por: Moldovan, Rareş-Petru, et al.
Publicado: (2017)

Advances in Fmoc solid‐phase peptide synthesis
por: Behrendt, Raymond, et al.
Publicado: (2016)

Peptide mini-scaffold facilitates JNK3 activation in cells
por: Zhan, Xuanzhi, et al.
Publicado: (2016)

Strategies for Site‐Specific Labeling of Receptor Proteins on the Surfaces of Living Cells by Using Genetically Encoded Peptide Tags
por: Wolf, Philipp, et al.
Publicado: (2021)

Integrating Solid-State NMR and Computational Modeling to Investigate the Structure and Dynamics of Membrane-Associated Ghrelin
por: Vortmeier, Gerrit, et al.
Publicado: (2015)

Solid-Phase Synthesis of Tetrahydropyridazinedione-Constrained Peptides
por: Kang, Chang Won, et al.
Publicado: (2014)

Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis
por: Liu, Dan, et al.
Publicado: (2018)

The Structural Basis of Peptide Binding at Class A G Protein-Coupled Receptors
por: Vu, Oanh, et al.
Publicado: (2021)

Expression, Functional Characterization, and Solid-State NMR Investigation of the G Protein-Coupled GHS Receptor in Bilayer Membranes
por: Schrottke, Stefanie, et al.
Publicado: (2017)

Design and validation of a frugal, automated, solid-phase peptide synthesizer
por: Kallmyer, Nathaniel E., et al.
Publicado: (2020)

Site-selective solid phase synthesis of carbonylated peptides
por: Waliczek, Mateusz, et al.
Publicado: (2015)

Solid Phase Peptide Synthesis on Chitosan Thin Films
por: Katan, Tadeja, et al.
Publicado: (2022)

Practical Protocols for Solid-Phase Peptide Synthesis 4.0
por: de la Torre, Beatriz G., et al.
Publicado: (2022)

Building Blocks for the Construction of Bioorthogonally Reactive Peptides via Solid-Phase Peptide Synthesis
por: Zeglis, Brian M, et al.
Publicado: (2014)

Lanthanide-Mediated Dephosphorylation Used for Peptide Cleavage during Solid Phase Peptide Synthesis
por: Yoo, Byunghee, et al.
Publicado: (2013)

Dipropyleneglycol Dimethylether, New Green Solvent for Solid-Phase Peptide Synthesis: Further Challenges to Improve Sustainability in the Development of Therapeutic Peptides
por: Vivenzio, Giovanni, et al.
Publicado: (2023)

Revisiting NO(2) as Protecting Group of Arginine in Solid-Phase Peptide Synthesis
por: Alhassan, Mahama, et al.
Publicado: (2020)

Cyclic Derivatives of the Chemerin C-Terminus as Metabolically Stable Agonists at the Chemokine-like Receptor 1 for Cancer Treatment
por: Fischer, Tobias F., et al.
Publicado: (2021)

Shuttling of Peptide‐Drug Conjugates by G Protein‐Coupled Receptors Is Significantly Improved by Pulsed Application
por: Ziffert, Isabelle, et al.
Publicado: (2020)

Automated Solid Phase Oligosaccharide Synthesis
por: Castagner, Bastien, et al.
Publicado: (2007)

Cysteine Pseudoprolines for Thiol Protection and Peptide Macrocyclization Enhancement in Fmoc-Based Solid-Phase Peptide Synthesis
por: Postma, Tobias M., et al.
Publicado: (2014)

Automated synthesis of backbone protected peptides
por: Abdel-Aal, Abu-Baker M., et al.
Publicado: (2014)

Automated Peptide Synthesizers and Glycoprotein Synthesis
por: Tian, Jiekang, et al.
Publicado: (2022)

Solid-phase synthesis of peptides containing aminoadipic semialdehyde moiety and their cyclisations
por: Kijewska, Monika, et al.
Publicado: (2018)

Solid-Phase Synthesis of Self-Assembling Multivalent π-Conjugated Peptides
por: Sanders, Allix M., et al.
Publicado: (2017)

A solid-phase approach for the synthesis of α-aminoboronic acid peptides
por: Daniels, Blake E., et al.
Publicado: (2018)

A Photolabile Carboxyl Protecting Group for Solid Phase Peptide Synthesis
por: Yang, Hongpeng, et al.
Publicado: (2021)

Covalent Epitope Decoration of Carbon Electrodes using Solid Phase Peptide Synthesis
por: Candelaria, Lindsay, et al.
Publicado: (2019)

Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold
por: Dixon, Mark J., et al.
Publicado: (2009)

Effect of Microwave Radiation on Enzymatic and Chemical Peptide Bond Synthesis on Solid Phase
por: Basso, Alessandra, et al.
Publicado: (2009)

A Tripeptide Approach to the Solid‐Phase Synthesis of Peptide Thioacids and N‐Glycopeptides
por: Schöwe, Markus Julian, et al.
Publicado: (2019)

Tea Bags for Fmoc Solid-Phase Peptide Synthesis: An Example of Circular Economy
por: Guzmán, Fanny, et al.
Publicado: (2021)

An improved method for the incorporation of fluoromethyl ketones into solid phase peptide synthesis techniques
por: Joshi, Dhira, et al.
Publicado: (2021)

Solid-Phase Synthesis of Gly-Ψ[CH(CF(3))NH]-Peptides
por: Sgorbati, Clara, et al.
Publicado: (2021)

Solid-phase fluorescent BODIPY–peptide synthesis via in situ dipyrrin construction
por: Wu, Yue, et al.
Publicado: (2020)

Mechanistic Study of Diketopiperazine Formation during Solid-Phase Peptide Synthesis of Tirzepatide
por: Wang, Jingyao, et al.
Publicado: (2022)

Development of a ghrelin receptor inverse agonist for positron emission tomography
por: Bergmann, Ralf, et al.
Publicado: (2021)

Automated Flow Synthesis of Peptide–PNA Conjugates
por: Li, Chengxi, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jpdsgnn8aj3s8it1ttn5j4tuo9