Synthesis of 1-[bis(trifluoromethyl)phosphine]-1’-oxazolinylferrocene ligands and their application in regio- and enantioselective Pd-catalyzed allylic alkylation of monosubstituted allyl substrates

A class of novel, easily accessible and air-stable 1-[bis(trifluoromethyl)phosphine]-1’-oxazolinylferrocene ligands has been synthesized from ferrocene. It became apparent that these ligands can be used in the regio- and enantioselective Pd-catalyzed allylic alkylation of monosubstituted allyl subst...

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Autores principales: Lai, Zeng-Wei, Yang, Rong-Fei, Ye, Ke-Yin, Sun, Hongbin, You, Shu-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077528/
https://www.ncbi.nlm.nih.gov/pubmed/24991277
http://dx.doi.org/10.3762/bjoc.10.126
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author Lai, Zeng-Wei
Yang, Rong-Fei
Ye, Ke-Yin
Sun, Hongbin
You, Shu-Li
author_facet Lai, Zeng-Wei
Yang, Rong-Fei
Ye, Ke-Yin
Sun, Hongbin
You, Shu-Li
author_sort Lai, Zeng-Wei
collection PubMed
description A class of novel, easily accessible and air-stable 1-[bis(trifluoromethyl)phosphine]-1’-oxazolinylferrocene ligands has been synthesized from ferrocene. It became apparent that these ligands can be used in the regio- and enantioselective Pd-catalyzed allylic alkylation of monosubstituted allyl substrates in a highly efficient manner. Excellent regio- and enantioselectivity could be obtained for a wide range of substrates.
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spelling pubmed-40775282014-07-02 Synthesis of 1-[bis(trifluoromethyl)phosphine]-1’-oxazolinylferrocene ligands and their application in regio- and enantioselective Pd-catalyzed allylic alkylation of monosubstituted allyl substrates Lai, Zeng-Wei Yang, Rong-Fei Ye, Ke-Yin Sun, Hongbin You, Shu-Li Beilstein J Org Chem Full Research Paper A class of novel, easily accessible and air-stable 1-[bis(trifluoromethyl)phosphine]-1’-oxazolinylferrocene ligands has been synthesized from ferrocene. It became apparent that these ligands can be used in the regio- and enantioselective Pd-catalyzed allylic alkylation of monosubstituted allyl substrates in a highly efficient manner. Excellent regio- and enantioselectivity could be obtained for a wide range of substrates. Beilstein-Institut 2014-05-30 /pmc/articles/PMC4077528/ /pubmed/24991277 http://dx.doi.org/10.3762/bjoc.10.126 Text en Copyright © 2014, Lai et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Lai, Zeng-Wei
Yang, Rong-Fei
Ye, Ke-Yin
Sun, Hongbin
You, Shu-Li
Synthesis of 1-[bis(trifluoromethyl)phosphine]-1’-oxazolinylferrocene ligands and their application in regio- and enantioselective Pd-catalyzed allylic alkylation of monosubstituted allyl substrates
title Synthesis of 1-[bis(trifluoromethyl)phosphine]-1’-oxazolinylferrocene ligands and their application in regio- and enantioselective Pd-catalyzed allylic alkylation of monosubstituted allyl substrates
title_full Synthesis of 1-[bis(trifluoromethyl)phosphine]-1’-oxazolinylferrocene ligands and their application in regio- and enantioselective Pd-catalyzed allylic alkylation of monosubstituted allyl substrates
title_fullStr Synthesis of 1-[bis(trifluoromethyl)phosphine]-1’-oxazolinylferrocene ligands and their application in regio- and enantioselective Pd-catalyzed allylic alkylation of monosubstituted allyl substrates
title_full_unstemmed Synthesis of 1-[bis(trifluoromethyl)phosphine]-1’-oxazolinylferrocene ligands and their application in regio- and enantioselective Pd-catalyzed allylic alkylation of monosubstituted allyl substrates
title_short Synthesis of 1-[bis(trifluoromethyl)phosphine]-1’-oxazolinylferrocene ligands and their application in regio- and enantioselective Pd-catalyzed allylic alkylation of monosubstituted allyl substrates
title_sort synthesis of 1-[bis(trifluoromethyl)phosphine]-1’-oxazolinylferrocene ligands and their application in regio- and enantioselective pd-catalyzed allylic alkylation of monosubstituted allyl substrates
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077528/
https://www.ncbi.nlm.nih.gov/pubmed/24991277
http://dx.doi.org/10.3762/bjoc.10.126
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