Anti-Retroviral Therapy Decreases but Does Not Normalize Indoleamine 2,3-Dioxygenase Activity in HIV-Infected Patients

BACKGROUND: Indoleamine 2,3-dioxygenase (IDO), which is mainly expressed in activated dendritic cells, catabolizes tryptophan to kynurenine and other downstream catabolites. It is known to be an immune mediator in HIV pathogenesis. The impact of anti-retroviral therapy on its activity has not been w...

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Detalles Bibliográficos
Autores principales: Chen, Jun, Shao, Jiasheng, Cai, Rentian, Shen, Yinzhong, Zhang, Renfang, Liu, Li, Qi, Tangkai, Lu, Hongzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077698/
https://www.ncbi.nlm.nih.gov/pubmed/24983463
http://dx.doi.org/10.1371/journal.pone.0100446

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