Interferon-stimulated genes: roles in viral pathogenesis

Interferon-stimulated genes (ISGs) are critical for controlling virus infections. As new antiviral ISGs continue to be identified and characterized, their roles in viral pathogenesis are also being explored in more detail. Our current understanding of how ISGs impact viral pathogenesis comes largely...

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Detalles Bibliográficos
Autor principal: Schoggins, John W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077717/
https://www.ncbi.nlm.nih.gov/pubmed/24713352
http://dx.doi.org/10.1016/j.coviro.2014.03.006
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author Schoggins, John W
author_facet Schoggins, John W
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description Interferon-stimulated genes (ISGs) are critical for controlling virus infections. As new antiviral ISGs continue to be identified and characterized, their roles in viral pathogenesis are also being explored in more detail. Our current understanding of how ISGs impact viral pathogenesis comes largely from studies in knockout mice, with isolated examples from human clinical data. This review outlines recent developments on the contributions of various ISGs to viral disease outcomes in vivo.
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spelling pubmed-40777172015-06-01 Interferon-stimulated genes: roles in viral pathogenesis Schoggins, John W Curr Opin Virol Article Interferon-stimulated genes (ISGs) are critical for controlling virus infections. As new antiviral ISGs continue to be identified and characterized, their roles in viral pathogenesis are also being explored in more detail. Our current understanding of how ISGs impact viral pathogenesis comes largely from studies in knockout mice, with isolated examples from human clinical data. This review outlines recent developments on the contributions of various ISGs to viral disease outcomes in vivo. Elsevier B.V. 2014-06 2014-04-05 /pmc/articles/PMC4077717/ /pubmed/24713352 http://dx.doi.org/10.1016/j.coviro.2014.03.006 Text en Copyright © 2014 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Schoggins, John W
Interferon-stimulated genes: roles in viral pathogenesis
title Interferon-stimulated genes: roles in viral pathogenesis
title_full Interferon-stimulated genes: roles in viral pathogenesis
title_fullStr Interferon-stimulated genes: roles in viral pathogenesis
title_full_unstemmed Interferon-stimulated genes: roles in viral pathogenesis
title_short Interferon-stimulated genes: roles in viral pathogenesis
title_sort interferon-stimulated genes: roles in viral pathogenesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077717/
https://www.ncbi.nlm.nih.gov/pubmed/24713352
http://dx.doi.org/10.1016/j.coviro.2014.03.006
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