Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

The type I interferon (IFN) response protects cells from viral infection by inducing hundreds of interferon-stimulated genes (ISGs), some of which encode direct antiviral effectors(1–3). Recent screening studies have begun to catalogue ISGs with antiviral activity against several RNA and DNA viruses...

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Detalles Bibliográficos
Autores principales: Schoggins, John W., MacDuff, Donna A., Imanaka, Naoko, Gainey, Maria D., Shrestha, Bimmi, Eitson, Jennifer L., Mar, Katrina B., Richardson, R. Blake, Ratushny, Alexander V., Litvak, Vladimir, Dabelic, Rea, Manicassamy, Balaji, Aitchison, John D., Aderem, Alan, Elliott, Richard M., García-Sastre, Adolfo, Racaniello, Vincent, Snijder, Eric J., Yokoyama, Wayne M., Diamond, Michael S., Virgin, Herbert W., Rice, Charles M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077721/
https://www.ncbi.nlm.nih.gov/pubmed/24284630
http://dx.doi.org/10.1038/nature12862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077721/
https://www.ncbi.nlm.nih.gov/pubmed/24284630
http://dx.doi.org/10.1038/nature12862

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