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COX-2 but Not mPGES-1 Contributes to Renal PGE2 Induction and Diabetic Proteinuria in Mice with Type-1 Diabetes

Prostaglandin E2 (PGE2) has been implicated to play a pathogenic role in diabetic nephropathy (DN) but its source remains unlcear. To elucidate whether mPGES-1, the best characterized PGE2 synthase, was involved in the development of DN, we examined the renal phenotype of mPGES-1 KO mice subjected t...

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Detalles Bibliográficos
Autores principales:	Jia, Zhanjun, Sun, Ying, Liu, Shanshan, Liu, Ying, Yang, Tianxin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077725/ https://www.ncbi.nlm.nih.gov/pubmed/24984018 http://dx.doi.org/10.1371/journal.pone.0093182

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