Genotyping Cancer-Associated Genes in Chordoma Identifies Mutations in Oncogenes and Areas of Chromosomal Loss Involving CDKN2A, PTEN, and SMARCB1

The molecular mechanisms underlying chordoma pathogenesis are unknown. We therefore sought to identify novel mutations to better understand chordoma biology and to potentially identify therapeutic targets. Given the relatively high costs of whole genome sequencing, we performed a focused genetic ana...

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Detalles Bibliográficos
Autores principales: Choy, Edwin, MacConaill, Laura E., Cote, Gregory M., Le, Long P., Shen, Jacson K., Nielsen, Gunnlaugur P., Iafrate, Anthony J., Garraway, Levi A., Hornicek, Francis J., Duan, Zhenfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077728/
https://www.ncbi.nlm.nih.gov/pubmed/24983247
http://dx.doi.org/10.1371/journal.pone.0101283

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