Telomerase Variant A279T Induces Telomere Dysfunction and Inhibits Non-Canonical Telomerase Activity in Esophageal Carcinomas

BACKGROUND: Although implicated in the pathogenesis of several chronic inflammatory disorders and hematologic malignancies, telomerase mutations have not been thoroughly characterized in human cancers. The present study was performed to examine the frequency and potential clinical relevance of telom...

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Detalles Bibliográficos
Autores principales: Zhang, Yuwei, Calado, Rodrigo, Rao, Mahadev, Hong, Julie A., Meeker, Alan K., Dumitriu, Bogdan, Atay, Scott, McCormick, Peter J., Garfield, Susan H., Wangsa, Danny, Padilla-Nash, Hesed M., Burkett, Sandra, Zhang, Mary, Kunst, Tricia F., Peterson, Nathan R., Xi, Sichuan, Inchauste, Suzanne, Altorki, Nasser K., Casson, Alan G., Beer, David G., Harris, Curtis C., Ried, Thomas, Young, Neal S., Schrump, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077737/
https://www.ncbi.nlm.nih.gov/pubmed/24983628
http://dx.doi.org/10.1371/journal.pone.0101010

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