Cargando…

The Smn-Independent Beneficial Effects of Trichostatin A on an Intermediate Mouse Model of Spinal Muscular Atrophy

Spinal muscular atrophy is an autosomal recessive neuromuscular disease characterized by the progressive loss of alpha motor neurons in the spinal cord. Trichostatin A (TSA) is a histone deacetylase inhibitor with beneficial effects in spinal muscular atrophy mouse models that carry the human SMN2 t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Hong, Yazdani, Armin, Murray, Lyndsay M., Beauvais, Ariane, Kothary, Rashmi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077776/ https://www.ncbi.nlm.nih.gov/pubmed/24984019 http://dx.doi.org/10.1371/journal.pone.0101225

Ejemplares similares

Defects in pancreatic development and glucose metabolism in SMN-depleted mice independent of canonical spinal muscular atrophy neuromuscular pathology
por: Bowerman, Melissa, et al.
Publicado: (2014)

Transcriptional profiling of differentially vulnerable motor neurons at pre-symptomatic stage in the Smn(2b/-) mouse model of spinal muscular atrophy
por: Murray, Lyndsay M., et al.
Publicado: (2015)

Effect of genetic background on the phenotype of the Smn(2B/-) mouse model of spinal muscular atrophy
por: Eshraghi, Mehdi, et al.
Publicado: (2016)

Low fat diets increase survival of a mouse model of spinal muscular atrophy
por: Deguise, Marc‐Olivier, et al.
Publicado: (2019)

Myogenic program dysregulation is contributory to disease pathogenesis in spinal muscular atrophy
por: Boyer, Justin G., et al.
Publicado: (2014)

Therapy Development for Spinal Muscular Atrophy in SMN Independent Targets
por: Tsai, Li-Kai
Publicado: (2012)

Differential induction of muscle atrophy pathways in two mouse models of spinal muscular atrophy
por: Deguise, Marc-Olivier, et al.
Publicado: (2016)

Motor unit recovery following Smn restoration in mouse models of spinal muscular atrophy
por: Comley, Laura H, et al.
Publicado: (2022)

The Need for SMN-Independent Treatments of Spinal Muscular Atrophy (SMA) to Complement SMN-Enhancing Drugs
por: Hensel, Niko, et al.
Publicado: (2020)

Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy
por: Bowerman, Melissa, et al.
Publicado: (2012)

Temporal and tissue-specific variability of SMN protein levels in mouse models of spinal muscular atrophy
por: Groen, Ewout J N, et al.
Publicado: (2018)

Early onset muscle weakness and disruption of muscle proteins in mouse models of spinal muscular atrophy
por: Boyer, Justin G, et al.
Publicado: (2013)

Therapeutic strategies for spinal muscular atrophy: SMN and beyond
por: Bowerman, Melissa, et al.
Publicado: (2017)

SMN post-translational modifications in spinal muscular atrophy
por: Riboldi, Giulietta M., et al.
Publicado: (2023)

Metabolic Dysfunction in Spinal Muscular Atrophy
por: Deguise, Marc-Olivier, et al.
Publicado: (2021)

Molecular Crosstalk Between Non-SMN-Related and SMN-Related Spinal Muscular Atrophy
por: Šoltić, Darija, et al.
Publicado: (2020)

CORRIGENDUM to Molecular Crosstalk Between Non-SMN-Related and SMN-Related Spinal Muscular Atrophy
Publicado: (2020)

Motor transmission defects with sex differences in a new mouse model of mild spinal muscular atrophy
por: Deguise, Marc-Olivier, et al.
Publicado: (2020)

SMN1 dosage analysis in spinal muscular atrophy from India
por: Kesari, Akanchha, et al.
Publicado: (2005)

Modeling spinal muscular atrophy in Drosophila links Smn to FGF signaling
por: Sen, Anindya, et al.
Publicado: (2011)

Deletion of SMN and NAIP genes in Korean patients with spinal muscular atrophy.
por: Shin, S., et al.
Publicado: (2000)

The Spinal Muscular Atrophy Disease Protein SMN Is Linked to the Golgi Network
por: Ting, Chen-Hung, et al.
Publicado: (2012)

25 years of the SMN genes: the Copernican revolution of spinal muscular atrophy
por: Tiziano, Francesco Danilo, et al.
Publicado: (2020)

SMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy
por: Valsecchi, Valeria, et al.
Publicado: (2023)

Mouse Survival Motor Neuron Alleles That Mimic SMN2 Splicing and Are Inducible Rescue Embryonic Lethality Early in Development but Not Late
por: Hammond, Suzan M., et al.
Publicado: (2010)

Base editing as a genetic treatment for spinal muscular atrophy
por: Alves, Christiano R. R., et al.
Publicado: (2023)

Lysine-Less Variants of Spinal Muscular Atrophy SMN and SMNΔ7 Proteins Are Degraded by the Proteasome Pathway
por: Sánchez-Lanzas, Raúl, et al.
Publicado: (2017)

Abnormal fatty acid metabolism is a core component of spinal muscular atrophy
por: Deguise, Marc‐Olivier, et al.
Publicado: (2019)

Suppression of the necroptotic cell death pathways improves survival in Smn(2B/−) mice
por: Chehade, Lucia, et al.
Publicado: (2022)

Clinical and genetic diversity of SMN1-negative proximal spinal muscular atrophies
por: Peeters, Kristien, et al.
Publicado: (2014)

Deletion analysis of SMN and NAIP genes in Tunisian patients with spinal muscular atrophy
por: Rekik, Imen, et al.
Publicado: (2013)

Targeting SR Proteins Improves SMN Expression in Spinal Muscular Atrophy Cells
por: Wee, Claribel D., et al.
Publicado: (2014)

SMN-primed ribosomes modulate the translation of transcripts related to Spinal Muscular Atrophy
por: Lauria, Fabio, et al.
Publicado: (2020)

Intragenic and structural variation in the SMN locus and clinical variability in spinal muscular atrophy
por: Wadman, Renske I, et al.
Publicado: (2020)

The Importance of Digging into the Genetics of SMN Genes in the Therapeutic Scenario of Spinal Muscular Atrophy
por: Costa-Roger, Mar, et al.
Publicado: (2021)

Restoring SMN Expression: An Overview of the Therapeutic Developments for the Treatment of Spinal Muscular Atrophy
por: Aslesh, Tejal, et al.
Publicado: (2022)

NSC Physiological Features in Spinal Muscular Atrophy: SMN Deficiency Effects on Neurogenesis
por: Adami, Raffaella, et al.
Publicado: (2022)

SAM68 is a physiological regulator of SMN2 splicing in spinal muscular atrophy
por: Pagliarini, Vittoria, et al.
Publicado: (2015)

Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes
por: Garcia-Lopez, Amparo, et al.
Publicado: (2018)

Stability and Oligomerization of Mutated SMN Protein Determine Clinical Severity of Spinal Muscular Atrophy
por: Niba, Emma Tabe Eko, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_t3lcuj1lrphuhs3qsb98jjq9sn