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Association between Exposure to HSV1 and Cognitive Functioning in a General Population of Adolescents. The TRAILS Study

BACKGROUND: Infections with different herpes viruses have been associated with cognitive functioning in psychiatric patients and healthy adults. The aim of this study was to find out whether antibodies to different herpes viruses are prospectively associated with cognitive functioning in a general a...

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Autores principales: Jonker, Iris, Klein, Hans C., Duivis, Hester E., Yolken, Robert H., Rosmalen, Judith G. M., Schoevers, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077793/
https://www.ncbi.nlm.nih.gov/pubmed/24983885
http://dx.doi.org/10.1371/journal.pone.0101549
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author Jonker, Iris
Klein, Hans C.
Duivis, Hester E.
Yolken, Robert H.
Rosmalen, Judith G. M.
Schoevers, Robert A.
author_facet Jonker, Iris
Klein, Hans C.
Duivis, Hester E.
Yolken, Robert H.
Rosmalen, Judith G. M.
Schoevers, Robert A.
author_sort Jonker, Iris
collection PubMed
description BACKGROUND: Infections with different herpes viruses have been associated with cognitive functioning in psychiatric patients and healthy adults. The aim of this study was to find out whether antibodies to different herpes viruses are prospectively associated with cognitive functioning in a general adolescent population. METHODS: This study was performed in TRAILS, a large prospective general population cohort (N = 1084, 54% female, mean age 16.2 years (SD 0.6)). At age 16, immunoglobulin G antibodies against HSV1, HSV2, CMV and EBV were measured next to high sensitive C-Reactive Protein (hsCRP). Two years later, immediate memory and executive functioning were assessed using the 15 words task and the self ordered pointing task. Multiple linear regression analysis with bootstrapping was performed to study the association between viral infections and cognitive function, adjusting for gender, socioeconomic status, ethnicity, and cannabis use. RESULTS: Presence of HSV1 antibodies was associated with memory function ((B = −0.272, 95% CI = −0.556 to −0.016, p = 0.047)), while the association with executive functioning did not reach statistical significance (B = 0.560, 95% CI is −0.053 to 1.184, p = 0.075). The level of HSV1 antibodies was associated with both memory function (B = −0.160, 95% CI = −0.280 to −0.039, p = 0.014) and executive functioning (B = 0.296, 95% CI = 0.011 to 0.578, p = 0.046). Other herpes viruses and hsCRP were not associated with cognitive functioning. CONCLUSIONS: Both presence and level of HSV1 antibodies are prospectively associated with reduced cognitive performance in a large cohort of adolescents.
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spelling pubmed-40777932014-07-03 Association between Exposure to HSV1 and Cognitive Functioning in a General Population of Adolescents. The TRAILS Study Jonker, Iris Klein, Hans C. Duivis, Hester E. Yolken, Robert H. Rosmalen, Judith G. M. Schoevers, Robert A. PLoS One Research Article BACKGROUND: Infections with different herpes viruses have been associated with cognitive functioning in psychiatric patients and healthy adults. The aim of this study was to find out whether antibodies to different herpes viruses are prospectively associated with cognitive functioning in a general adolescent population. METHODS: This study was performed in TRAILS, a large prospective general population cohort (N = 1084, 54% female, mean age 16.2 years (SD 0.6)). At age 16, immunoglobulin G antibodies against HSV1, HSV2, CMV and EBV were measured next to high sensitive C-Reactive Protein (hsCRP). Two years later, immediate memory and executive functioning were assessed using the 15 words task and the self ordered pointing task. Multiple linear regression analysis with bootstrapping was performed to study the association between viral infections and cognitive function, adjusting for gender, socioeconomic status, ethnicity, and cannabis use. RESULTS: Presence of HSV1 antibodies was associated with memory function ((B = −0.272, 95% CI = −0.556 to −0.016, p = 0.047)), while the association with executive functioning did not reach statistical significance (B = 0.560, 95% CI is −0.053 to 1.184, p = 0.075). The level of HSV1 antibodies was associated with both memory function (B = −0.160, 95% CI = −0.280 to −0.039, p = 0.014) and executive functioning (B = 0.296, 95% CI = 0.011 to 0.578, p = 0.046). Other herpes viruses and hsCRP were not associated with cognitive functioning. CONCLUSIONS: Both presence and level of HSV1 antibodies are prospectively associated with reduced cognitive performance in a large cohort of adolescents. Public Library of Science 2014-07-01 /pmc/articles/PMC4077793/ /pubmed/24983885 http://dx.doi.org/10.1371/journal.pone.0101549 Text en © 2014 Jonker et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Jonker, Iris
Klein, Hans C.
Duivis, Hester E.
Yolken, Robert H.
Rosmalen, Judith G. M.
Schoevers, Robert A.
Association between Exposure to HSV1 and Cognitive Functioning in a General Population of Adolescents. The TRAILS Study
title Association between Exposure to HSV1 and Cognitive Functioning in a General Population of Adolescents. The TRAILS Study
title_full Association between Exposure to HSV1 and Cognitive Functioning in a General Population of Adolescents. The TRAILS Study
title_fullStr Association between Exposure to HSV1 and Cognitive Functioning in a General Population of Adolescents. The TRAILS Study
title_full_unstemmed Association between Exposure to HSV1 and Cognitive Functioning in a General Population of Adolescents. The TRAILS Study
title_short Association between Exposure to HSV1 and Cognitive Functioning in a General Population of Adolescents. The TRAILS Study
title_sort association between exposure to hsv1 and cognitive functioning in a general population of adolescents. the trails study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077793/
https://www.ncbi.nlm.nih.gov/pubmed/24983885
http://dx.doi.org/10.1371/journal.pone.0101549
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