Decreased miR-204 in H. pylori-Associated Gastric Cancer Promotes Cancer Cell Proliferation and Invasion by Targeting SOX4

BACKGROUND: The molecular mechanism between Helicobacter pylori (H. pylori) infection and gastric cancer remained largely unknown. In this study, we determined the role of miRNA in H. pylori induced gastric cancer. METHODS AND RESULTS: We found that miR-204 was decreased in H. pylori positive tissue...

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Detalles Bibliográficos
Autores principales: Zhou, Xiaoying, Li, Lin, Su, Jing, Zhang, Guoxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077842/
https://www.ncbi.nlm.nih.gov/pubmed/24984017
http://dx.doi.org/10.1371/journal.pone.0101457
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author Zhou, Xiaoying
Li, Lin
Su, Jing
Zhang, Guoxin
author_facet Zhou, Xiaoying
Li, Lin
Su, Jing
Zhang, Guoxin
author_sort Zhou, Xiaoying
collection PubMed
description BACKGROUND: The molecular mechanism between Helicobacter pylori (H. pylori) infection and gastric cancer remained largely unknown. In this study, we determined the role of miRNA in H. pylori induced gastric cancer. METHODS AND RESULTS: We found that miR-204 was decreased in H. pylori positive tissues by qRT-PCR. Knockdown of miR-204 enhanced the invasion and proliferation ability of gastric cancer cells in vitro. Luciferase assay revealed that SOX4 was target gene of miR-204, which was found up-regulated in H. pylori positive tissues. Down-regulation of miR-204 and over-expression of SOX4 promoted epithelial-mesenchymal transition process. CONCLUSION: Taken together, our findings demonstrated that miR-204 may act as a tumor suppressor in H. pylori induced gastric cancer by targeting SOX4.
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spelling pubmed-40778422014-07-03 Decreased miR-204 in H. pylori-Associated Gastric Cancer Promotes Cancer Cell Proliferation and Invasion by Targeting SOX4 Zhou, Xiaoying Li, Lin Su, Jing Zhang, Guoxin PLoS One Research Article BACKGROUND: The molecular mechanism between Helicobacter pylori (H. pylori) infection and gastric cancer remained largely unknown. In this study, we determined the role of miRNA in H. pylori induced gastric cancer. METHODS AND RESULTS: We found that miR-204 was decreased in H. pylori positive tissues by qRT-PCR. Knockdown of miR-204 enhanced the invasion and proliferation ability of gastric cancer cells in vitro. Luciferase assay revealed that SOX4 was target gene of miR-204, which was found up-regulated in H. pylori positive tissues. Down-regulation of miR-204 and over-expression of SOX4 promoted epithelial-mesenchymal transition process. CONCLUSION: Taken together, our findings demonstrated that miR-204 may act as a tumor suppressor in H. pylori induced gastric cancer by targeting SOX4. Public Library of Science 2014-07-01 /pmc/articles/PMC4077842/ /pubmed/24984017 http://dx.doi.org/10.1371/journal.pone.0101457 Text en © 2014 Zhou et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Zhou, Xiaoying
Li, Lin
Su, Jing
Zhang, Guoxin
Decreased miR-204 in H. pylori-Associated Gastric Cancer Promotes Cancer Cell Proliferation and Invasion by Targeting SOX4
title Decreased miR-204 in H. pylori-Associated Gastric Cancer Promotes Cancer Cell Proliferation and Invasion by Targeting SOX4
title_full Decreased miR-204 in H. pylori-Associated Gastric Cancer Promotes Cancer Cell Proliferation and Invasion by Targeting SOX4
title_fullStr Decreased miR-204 in H. pylori-Associated Gastric Cancer Promotes Cancer Cell Proliferation and Invasion by Targeting SOX4
title_full_unstemmed Decreased miR-204 in H. pylori-Associated Gastric Cancer Promotes Cancer Cell Proliferation and Invasion by Targeting SOX4
title_short Decreased miR-204 in H. pylori-Associated Gastric Cancer Promotes Cancer Cell Proliferation and Invasion by Targeting SOX4
title_sort decreased mir-204 in h. pylori-associated gastric cancer promotes cancer cell proliferation and invasion by targeting sox4
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077842/
https://www.ncbi.nlm.nih.gov/pubmed/24984017
http://dx.doi.org/10.1371/journal.pone.0101457
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