T cell immunosurveillance controls B lymphoma development

We recently showed a critical role for T cells in the immunosurveillance of nascent B cell lymphomas arising from mutations impacting plasma cell differentiation. Our data suggest that CD8(+) T cells continuously eliminate mutated B cells that fail to downregulate their co-stimulatory machinery and...

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Detalles Bibliográficos
Autor principal: Kallies, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077859/
https://www.ncbi.nlm.nih.gov/pubmed/25050223
http://dx.doi.org/10.4161/onci.28697
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author Kallies, Axel
author_facet Kallies, Axel
author_sort Kallies, Axel
collection PubMed
description We recently showed a critical role for T cells in the immunosurveillance of nascent B cell lymphomas arising from mutations impacting plasma cell differentiation. Our data suggest that CD8(+) T cells continuously eliminate mutated B cells that fail to downregulate their co-stimulatory machinery and the Fas death receptor, thus constraining B lymphoma pathogenesis.
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spelling pubmed-40778592014-07-21 T cell immunosurveillance controls B lymphoma development Kallies, Axel Oncoimmunology Author's View We recently showed a critical role for T cells in the immunosurveillance of nascent B cell lymphomas arising from mutations impacting plasma cell differentiation. Our data suggest that CD8(+) T cells continuously eliminate mutated B cells that fail to downregulate their co-stimulatory machinery and the Fas death receptor, thus constraining B lymphoma pathogenesis. Landes Bioscience 2014-04-29 /pmc/articles/PMC4077859/ /pubmed/25050223 http://dx.doi.org/10.4161/onci.28697 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Kallies, Axel
T cell immunosurveillance controls B lymphoma development
title T cell immunosurveillance controls B lymphoma development
title_full T cell immunosurveillance controls B lymphoma development
title_fullStr T cell immunosurveillance controls B lymphoma development
title_full_unstemmed T cell immunosurveillance controls B lymphoma development
title_short T cell immunosurveillance controls B lymphoma development
title_sort t cell immunosurveillance controls b lymphoma development
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077859/
https://www.ncbi.nlm.nih.gov/pubmed/25050223
http://dx.doi.org/10.4161/onci.28697
work_keys_str_mv AT kalliesaxel tcellimmunosurveillancecontrolsblymphomadevelopment

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