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A biocompatible synthesis of gold nanoparticles by Tris(hydroxymethyl)aminomethane
Gold nanoparticles' novel properties are widely realized in catalysis, plasmonics, electronics, and biomedical applications. For biomedical application, one challenge is to find a non-toxic chemical and/or physical method of functionalizing gold nanoparticles with biomolecular compounds that ca...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078098/ https://www.ncbi.nlm.nih.gov/pubmed/25006333 http://dx.doi.org/10.1186/1556-276X-9-220 |
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author | Chen, Feng Wang, Yanwei Ma, Jun Yang, Guangcan |
author_facet | Chen, Feng Wang, Yanwei Ma, Jun Yang, Guangcan |
author_sort | Chen, Feng |
collection | PubMed |
description | Gold nanoparticles' novel properties are widely realized in catalysis, plasmonics, electronics, and biomedical applications. For biomedical application, one challenge is to find a non-toxic chemical and/or physical method of functionalizing gold nanoparticles with biomolecular compounds that can promote efficient binding, clearance, and biocompatibility and to assess their safety to other biological systems and their long-term effects on human health and reproduction. In the present study, we describe a new method by using Tris(hydroxymethyl)aminomethane (Tris), a widely used buffer solvent of nucleic acid and proteins, as the reducing agent for synthesizing gold nanoparticles by one step. It is found that Tris carries out the reduction reactions in relatively mild conditions for biomacromolecules. Particularly, it can be used to modify the DNA during the process of preparation of gold nanoparticles. The morphology and size distribution of gold nanoparticles are consistent and were confirmed by many different approaches including dynamic light scattering (DLS), UV-visible (UV-vis) spectrophotometry, atomic force microscopy (AFM), and transmission electron microscopy (TEM). |
format | Online Article Text |
id | pubmed-4078098 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer |
record_format | MEDLINE/PubMed |
spelling | pubmed-40780982014-07-08 A biocompatible synthesis of gold nanoparticles by Tris(hydroxymethyl)aminomethane Chen, Feng Wang, Yanwei Ma, Jun Yang, Guangcan Nanoscale Res Lett Nano Express Gold nanoparticles' novel properties are widely realized in catalysis, plasmonics, electronics, and biomedical applications. For biomedical application, one challenge is to find a non-toxic chemical and/or physical method of functionalizing gold nanoparticles with biomolecular compounds that can promote efficient binding, clearance, and biocompatibility and to assess their safety to other biological systems and their long-term effects on human health and reproduction. In the present study, we describe a new method by using Tris(hydroxymethyl)aminomethane (Tris), a widely used buffer solvent of nucleic acid and proteins, as the reducing agent for synthesizing gold nanoparticles by one step. It is found that Tris carries out the reduction reactions in relatively mild conditions for biomacromolecules. Particularly, it can be used to modify the DNA during the process of preparation of gold nanoparticles. The morphology and size distribution of gold nanoparticles are consistent and were confirmed by many different approaches including dynamic light scattering (DLS), UV-visible (UV-vis) spectrophotometry, atomic force microscopy (AFM), and transmission electron microscopy (TEM). Springer 2014-05-07 /pmc/articles/PMC4078098/ /pubmed/25006333 http://dx.doi.org/10.1186/1556-276X-9-220 Text en Copyright © 2014 Chen et al.; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
spellingShingle | Nano Express Chen, Feng Wang, Yanwei Ma, Jun Yang, Guangcan A biocompatible synthesis of gold nanoparticles by Tris(hydroxymethyl)aminomethane |
title | A biocompatible synthesis of gold nanoparticles by Tris(hydroxymethyl)aminomethane |
title_full | A biocompatible synthesis of gold nanoparticles by Tris(hydroxymethyl)aminomethane |
title_fullStr | A biocompatible synthesis of gold nanoparticles by Tris(hydroxymethyl)aminomethane |
title_full_unstemmed | A biocompatible synthesis of gold nanoparticles by Tris(hydroxymethyl)aminomethane |
title_short | A biocompatible synthesis of gold nanoparticles by Tris(hydroxymethyl)aminomethane |
title_sort | biocompatible synthesis of gold nanoparticles by tris(hydroxymethyl)aminomethane |
topic | Nano Express |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078098/ https://www.ncbi.nlm.nih.gov/pubmed/25006333 http://dx.doi.org/10.1186/1556-276X-9-220 |
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