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Evolution of Drug Resistance in Tuberculosis: Recent Progress and Implications for Diagnosis and Therapy

Drug-resistant tuberculosis is a growing threat to global public health. Recent efforts to understand the evolution of drug resistance have shown that changes in drug–target interactions are only the first step in a longer adaptive process. The emergence of transmissible drug-resistant Mycobacterium...

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Autores principales: Trauner, Andrej, Borrell, Sonia, Reither, Klaus, Gagneux, Sebastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078235/
https://www.ncbi.nlm.nih.gov/pubmed/24962424
http://dx.doi.org/10.1007/s40265-014-0248-y
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author Trauner, Andrej
Borrell, Sonia
Reither, Klaus
Gagneux, Sebastien
author_facet Trauner, Andrej
Borrell, Sonia
Reither, Klaus
Gagneux, Sebastien
author_sort Trauner, Andrej
collection PubMed
description Drug-resistant tuberculosis is a growing threat to global public health. Recent efforts to understand the evolution of drug resistance have shown that changes in drug–target interactions are only the first step in a longer adaptive process. The emergence of transmissible drug-resistant Mycobacterium tuberculosis is the result of a multitude of additional genetic mutations, many of which interact, a phenomenon known as epistasis. The varied effects of these epistatic interactions include compensating for the reduction of the biological cost associated with the development of drug resistance, increasing the level of resistance, and possibly accommodating broader changes in the physiology of resistant bacteria. Knowledge of these processes and our ability to detect them as they happen informs the development of diagnostic tools and better control strategies. In particular, the use of whole genome sequencing combined with surveillance efforts in the field could provide a powerful instrument to prevent future epidemics of drug-resistant tuberculosis.
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spelling pubmed-40782352014-07-25 Evolution of Drug Resistance in Tuberculosis: Recent Progress and Implications for Diagnosis and Therapy Trauner, Andrej Borrell, Sonia Reither, Klaus Gagneux, Sebastien Drugs Current Opinion Drug-resistant tuberculosis is a growing threat to global public health. Recent efforts to understand the evolution of drug resistance have shown that changes in drug–target interactions are only the first step in a longer adaptive process. The emergence of transmissible drug-resistant Mycobacterium tuberculosis is the result of a multitude of additional genetic mutations, many of which interact, a phenomenon known as epistasis. The varied effects of these epistatic interactions include compensating for the reduction of the biological cost associated with the development of drug resistance, increasing the level of resistance, and possibly accommodating broader changes in the physiology of resistant bacteria. Knowledge of these processes and our ability to detect them as they happen informs the development of diagnostic tools and better control strategies. In particular, the use of whole genome sequencing combined with surveillance efforts in the field could provide a powerful instrument to prevent future epidemics of drug-resistant tuberculosis. Springer International Publishing 2014-06-25 2014 /pmc/articles/PMC4078235/ /pubmed/24962424 http://dx.doi.org/10.1007/s40265-014-0248-y Text en © The Author(s) 2014 https://creativecommons.org/licenses/by-nc/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Current Opinion
Trauner, Andrej
Borrell, Sonia
Reither, Klaus
Gagneux, Sebastien
Evolution of Drug Resistance in Tuberculosis: Recent Progress and Implications for Diagnosis and Therapy
title Evolution of Drug Resistance in Tuberculosis: Recent Progress and Implications for Diagnosis and Therapy
title_full Evolution of Drug Resistance in Tuberculosis: Recent Progress and Implications for Diagnosis and Therapy
title_fullStr Evolution of Drug Resistance in Tuberculosis: Recent Progress and Implications for Diagnosis and Therapy
title_full_unstemmed Evolution of Drug Resistance in Tuberculosis: Recent Progress and Implications for Diagnosis and Therapy
title_short Evolution of Drug Resistance in Tuberculosis: Recent Progress and Implications for Diagnosis and Therapy
title_sort evolution of drug resistance in tuberculosis: recent progress and implications for diagnosis and therapy
topic Current Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078235/
https://www.ncbi.nlm.nih.gov/pubmed/24962424
http://dx.doi.org/10.1007/s40265-014-0248-y
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