Evolution of Our Understanding of Myeloid Regulatory Cells: From MDSCs to Mregs

The term myeloid-derived suppressor cells (MDSCs) was first suggested in 2007 in order to reflect the origin and function of myeloid cells during immunosuppression in cancer and other pathologic conditions. Emerging evidence suggests that MDSCs suppress CTL and Th1 responses in malignant diseases wh...

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Detalles Bibliográficos
Autores principales: Manjili, Masoud H., Wang, Xiang-Yang, Abrams, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078244/
https://www.ncbi.nlm.nih.gov/pubmed/25071764
http://dx.doi.org/10.3389/fimmu.2014.00303
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author Manjili, Masoud H.
Wang, Xiang-Yang
Abrams, Scott
author_facet Manjili, Masoud H.
Wang, Xiang-Yang
Abrams, Scott
author_sort Manjili, Masoud H.
collection PubMed
description The term myeloid-derived suppressor cells (MDSCs) was first suggested in 2007 in order to reflect the origin and function of myeloid cells during immunosuppression in cancer and other pathologic conditions. Emerging evidence suggests that MDSCs suppress CTL and Th1 responses in malignant diseases while they regulate effective immune responses in parasitic and helminth infections as well as Th17 inflammatory response during autoimmune diseases. Based on these data, the term myeloid regulatory cells (Mregs) more accurately reflects their function and interactions with different cells of the immune system during diseased conditions. Here, we provide evidence on the multifaceted function of Mregs during diseased states.
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spelling pubmed-40782442014-07-28 Evolution of Our Understanding of Myeloid Regulatory Cells: From MDSCs to Mregs Manjili, Masoud H. Wang, Xiang-Yang Abrams, Scott Front Immunol Immunology The term myeloid-derived suppressor cells (MDSCs) was first suggested in 2007 in order to reflect the origin and function of myeloid cells during immunosuppression in cancer and other pathologic conditions. Emerging evidence suggests that MDSCs suppress CTL and Th1 responses in malignant diseases while they regulate effective immune responses in parasitic and helminth infections as well as Th17 inflammatory response during autoimmune diseases. Based on these data, the term myeloid regulatory cells (Mregs) more accurately reflects their function and interactions with different cells of the immune system during diseased conditions. Here, we provide evidence on the multifaceted function of Mregs during diseased states. Frontiers Media S.A. 2014-07-02 /pmc/articles/PMC4078244/ /pubmed/25071764 http://dx.doi.org/10.3389/fimmu.2014.00303 Text en Copyright © 2014 Manjili, Wang and Abrams. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Manjili, Masoud H.
Wang, Xiang-Yang
Abrams, Scott
Evolution of Our Understanding of Myeloid Regulatory Cells: From MDSCs to Mregs
title Evolution of Our Understanding of Myeloid Regulatory Cells: From MDSCs to Mregs
title_full Evolution of Our Understanding of Myeloid Regulatory Cells: From MDSCs to Mregs
title_fullStr Evolution of Our Understanding of Myeloid Regulatory Cells: From MDSCs to Mregs
title_full_unstemmed Evolution of Our Understanding of Myeloid Regulatory Cells: From MDSCs to Mregs
title_short Evolution of Our Understanding of Myeloid Regulatory Cells: From MDSCs to Mregs
title_sort evolution of our understanding of myeloid regulatory cells: from mdscs to mregs
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078244/
https://www.ncbi.nlm.nih.gov/pubmed/25071764
http://dx.doi.org/10.3389/fimmu.2014.00303
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