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Effects of hydrogen-rich water on aging periodontal tissues in rats

Oxidative damage is involved in age-related inflammatory reactions. The anti-oxidative effects of hydrogen-rich water suppress oxidative damage, which may aid in inhibiting age-related inflammatory reactions. We investigated the effects of drinking hydrogen-rich water on aging periodontal tissues in...

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Autores principales: Tomofuji, Takaaki, Kawabata, Yuya, Kasuyama, Kenta, Endo, Yasumasa, Yoneda, Toshiki, Yamane, Mayu, Azuma, Tetsuji, Ekuni, Daisuke, Morita, Manabu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078318/
https://www.ncbi.nlm.nih.gov/pubmed/24985521
http://dx.doi.org/10.1038/srep05534
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author Tomofuji, Takaaki
Kawabata, Yuya
Kasuyama, Kenta
Endo, Yasumasa
Yoneda, Toshiki
Yamane, Mayu
Azuma, Tetsuji
Ekuni, Daisuke
Morita, Manabu
author_facet Tomofuji, Takaaki
Kawabata, Yuya
Kasuyama, Kenta
Endo, Yasumasa
Yoneda, Toshiki
Yamane, Mayu
Azuma, Tetsuji
Ekuni, Daisuke
Morita, Manabu
author_sort Tomofuji, Takaaki
collection PubMed
description Oxidative damage is involved in age-related inflammatory reactions. The anti-oxidative effects of hydrogen-rich water suppress oxidative damage, which may aid in inhibiting age-related inflammatory reactions. We investigated the effects of drinking hydrogen-rich water on aging periodontal tissues in healthy rats. Four-month-old male Fischer 344 rats (n = 12) were divided into two groups: the experimental group (hydrogen-rich water treatment) and the control group (distilled water treatment). The rats consumed hydrogen-rich water or distilled water until 16 months of age. The experimental group exhibited lower periodontal oxidative damage at 16 months of age than the control group. Although protein expression of interleukin-1β did not differ, gene expression of Nod-like receptor protein 3 inflammasomes was activated in periodontal tissues from the experimental group as compared with the control group. Drinking hydrogen-rich water is proposed to have anti-aging effects on periodontal oxidative damage, but not on inflammatory reactions in healthy rats.
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spelling pubmed-40783182014-07-03 Effects of hydrogen-rich water on aging periodontal tissues in rats Tomofuji, Takaaki Kawabata, Yuya Kasuyama, Kenta Endo, Yasumasa Yoneda, Toshiki Yamane, Mayu Azuma, Tetsuji Ekuni, Daisuke Morita, Manabu Sci Rep Article Oxidative damage is involved in age-related inflammatory reactions. The anti-oxidative effects of hydrogen-rich water suppress oxidative damage, which may aid in inhibiting age-related inflammatory reactions. We investigated the effects of drinking hydrogen-rich water on aging periodontal tissues in healthy rats. Four-month-old male Fischer 344 rats (n = 12) were divided into two groups: the experimental group (hydrogen-rich water treatment) and the control group (distilled water treatment). The rats consumed hydrogen-rich water or distilled water until 16 months of age. The experimental group exhibited lower periodontal oxidative damage at 16 months of age than the control group. Although protein expression of interleukin-1β did not differ, gene expression of Nod-like receptor protein 3 inflammasomes was activated in periodontal tissues from the experimental group as compared with the control group. Drinking hydrogen-rich water is proposed to have anti-aging effects on periodontal oxidative damage, but not on inflammatory reactions in healthy rats. Nature Publishing Group 2014-07-02 /pmc/articles/PMC4078318/ /pubmed/24985521 http://dx.doi.org/10.1038/srep05534 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Tomofuji, Takaaki
Kawabata, Yuya
Kasuyama, Kenta
Endo, Yasumasa
Yoneda, Toshiki
Yamane, Mayu
Azuma, Tetsuji
Ekuni, Daisuke
Morita, Manabu
Effects of hydrogen-rich water on aging periodontal tissues in rats
title Effects of hydrogen-rich water on aging periodontal tissues in rats
title_full Effects of hydrogen-rich water on aging periodontal tissues in rats
title_fullStr Effects of hydrogen-rich water on aging periodontal tissues in rats
title_full_unstemmed Effects of hydrogen-rich water on aging periodontal tissues in rats
title_short Effects of hydrogen-rich water on aging periodontal tissues in rats
title_sort effects of hydrogen-rich water on aging periodontal tissues in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078318/
https://www.ncbi.nlm.nih.gov/pubmed/24985521
http://dx.doi.org/10.1038/srep05534
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