Cargando…

Luteolin, a bioflavonoid inhibits azoxymethane-induced colon carcinogenesis: Involvement of iNOS and COX-2

Colon cancer (CRC) is a serious health problem through worldwide. Development of novel drug without side effect for this cancer was crucial. Luteolin (LUT), a bioflavonoid has many beneficial effects such as antioxidant, anti-inflammatory, anti-proliferative properties. Azoxymethane (AOM), a derivat...

Descripción completa

Detalles Bibliográficos
Autores principales: Pandurangan, Ashok Kumar, Kumar, Suresh Ananda Sadagopan, Dharmalingam, Prakash, Ganapasam, Sudhandiran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078326/
https://www.ncbi.nlm.nih.gov/pubmed/24991108
http://dx.doi.org/10.4103/0973-1296.133285
_version_ 1782323716818993152
author Pandurangan, Ashok Kumar
Kumar, Suresh Ananda Sadagopan
Dharmalingam, Prakash
Ganapasam, Sudhandiran
author_facet Pandurangan, Ashok Kumar
Kumar, Suresh Ananda Sadagopan
Dharmalingam, Prakash
Ganapasam, Sudhandiran
author_sort Pandurangan, Ashok Kumar
collection PubMed
description Colon cancer (CRC) is a serious health problem through worldwide. Development of novel drug without side effect for this cancer was crucial. Luteolin (LUT), a bioflavonoid has many beneficial effects such as antioxidant, anti-inflammatory, anti-proliferative properties. Azoxymethane (AOM), a derivative of 1, 2-Dimethyl hydrazine (DMH) was used for the induction of CRC in Balb/C mice. CRC was induced by intraperitoneal injection of AOM to mice at the dose of 15 mg/body kg weight for 3 weeks. Mouse was treated with LUT at the dose of 1.2 mg/body kg weight orally until end of the experiment. The expression of inducible nitric oxide synthase (iNOS) and cyclooxygense (COX)-2 were analyzed by RT-PCR and immunohistochemistry. The expressions of iNOS and COX-2 were increased in the case of AOM induction. Administration of LUT effectively reduced the expressions of iNOS and COX-2. The present study revealed that, LUT suppresses both iNOS and COX-2 expressions and act as an anti-inflammatory role against CRC.
format Online
Article
Text
id pubmed-4078326
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-40783262014-07-02 Luteolin, a bioflavonoid inhibits azoxymethane-induced colon carcinogenesis: Involvement of iNOS and COX-2 Pandurangan, Ashok Kumar Kumar, Suresh Ananda Sadagopan Dharmalingam, Prakash Ganapasam, Sudhandiran Pharmacogn Mag Original Article Colon cancer (CRC) is a serious health problem through worldwide. Development of novel drug without side effect for this cancer was crucial. Luteolin (LUT), a bioflavonoid has many beneficial effects such as antioxidant, anti-inflammatory, anti-proliferative properties. Azoxymethane (AOM), a derivative of 1, 2-Dimethyl hydrazine (DMH) was used for the induction of CRC in Balb/C mice. CRC was induced by intraperitoneal injection of AOM to mice at the dose of 15 mg/body kg weight for 3 weeks. Mouse was treated with LUT at the dose of 1.2 mg/body kg weight orally until end of the experiment. The expression of inducible nitric oxide synthase (iNOS) and cyclooxygense (COX)-2 were analyzed by RT-PCR and immunohistochemistry. The expressions of iNOS and COX-2 were increased in the case of AOM induction. Administration of LUT effectively reduced the expressions of iNOS and COX-2. The present study revealed that, LUT suppresses both iNOS and COX-2 expressions and act as an anti-inflammatory role against CRC. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4078326/ /pubmed/24991108 http://dx.doi.org/10.4103/0973-1296.133285 Text en Copyright: © Pharmacognosy Magazine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Pandurangan, Ashok Kumar
Kumar, Suresh Ananda Sadagopan
Dharmalingam, Prakash
Ganapasam, Sudhandiran
Luteolin, a bioflavonoid inhibits azoxymethane-induced colon carcinogenesis: Involvement of iNOS and COX-2
title Luteolin, a bioflavonoid inhibits azoxymethane-induced colon carcinogenesis: Involvement of iNOS and COX-2
title_full Luteolin, a bioflavonoid inhibits azoxymethane-induced colon carcinogenesis: Involvement of iNOS and COX-2
title_fullStr Luteolin, a bioflavonoid inhibits azoxymethane-induced colon carcinogenesis: Involvement of iNOS and COX-2
title_full_unstemmed Luteolin, a bioflavonoid inhibits azoxymethane-induced colon carcinogenesis: Involvement of iNOS and COX-2
title_short Luteolin, a bioflavonoid inhibits azoxymethane-induced colon carcinogenesis: Involvement of iNOS and COX-2
title_sort luteolin, a bioflavonoid inhibits azoxymethane-induced colon carcinogenesis: involvement of inos and cox-2
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078326/
https://www.ncbi.nlm.nih.gov/pubmed/24991108
http://dx.doi.org/10.4103/0973-1296.133285
work_keys_str_mv AT panduranganashokkumar luteolinabioflavonoidinhibitsazoxymethaneinducedcoloncarcinogenesisinvolvementofinosandcox2
AT kumarsureshanandasadagopan luteolinabioflavonoidinhibitsazoxymethaneinducedcoloncarcinogenesisinvolvementofinosandcox2
AT dharmalingamprakash luteolinabioflavonoidinhibitsazoxymethaneinducedcoloncarcinogenesisinvolvementofinosandcox2
AT ganapasamsudhandiran luteolinabioflavonoidinhibitsazoxymethaneinducedcoloncarcinogenesisinvolvementofinosandcox2