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Inhibitory effects of ginseng seed on melanin biosynthesis

BACKGROUND: Ginseng root has been traditionally used for the treatment of many diseases in Korea. However, so far ginseng seed has been mostly unused and discarded. As part of our ongoing research on the ginseng seeds, the inhibitory effect of ginseng seeds on melanin production was verified to asse...

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Autores principales: Lee, Yeonmi, Kim, Kyoung-Tack, Kim, Sung Soo, Hur, Jinyoung, Ha, Sang Keun, Cho, Chang-Won, Choi, Sang Yoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078335/
https://www.ncbi.nlm.nih.gov/pubmed/24991102
http://dx.doi.org/10.4103/0973-1296.133271
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author Lee, Yeonmi
Kim, Kyoung-Tack
Kim, Sung Soo
Hur, Jinyoung
Ha, Sang Keun
Cho, Chang-Won
Choi, Sang Yoon
author_facet Lee, Yeonmi
Kim, Kyoung-Tack
Kim, Sung Soo
Hur, Jinyoung
Ha, Sang Keun
Cho, Chang-Won
Choi, Sang Yoon
author_sort Lee, Yeonmi
collection PubMed
description BACKGROUND: Ginseng root has been traditionally used for the treatment of many diseases in Korea. However, so far ginseng seed has been mostly unused and discarded. As part of our ongoing research on the ginseng seeds, the inhibitory effect of ginseng seeds on melanin production was verified to assess their potential as a skin depigmenting substance. MATERIALS AND METHODS: The present study measured the inhibitory effect of ginseng seeds on melanin production through the tyrosinase inhibitory effect and analyzed their effects on melanin production in melan-a-cells. RESULTS: Ethanol extract of ginseng seed was applied to melan-a-cells at a concentration of 100 ppm and melanin production was reduced by 35.1% without cytotoxicity. In addition, the ethanol extract of ginseng seed was shown to reduce tyrosinase activity. CONCLUSION: Because the results showed excellent melanin inhibitory activity compared with that obtained by arbutin, ethanol extracts of ginseng leaf and ginseng root at the same concentration, it can be concluded that ginseng seeds show great potential as a skin depigmenting substance.
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spelling pubmed-40783352014-07-02 Inhibitory effects of ginseng seed on melanin biosynthesis Lee, Yeonmi Kim, Kyoung-Tack Kim, Sung Soo Hur, Jinyoung Ha, Sang Keun Cho, Chang-Won Choi, Sang Yoon Pharmacogn Mag Original Article BACKGROUND: Ginseng root has been traditionally used for the treatment of many diseases in Korea. However, so far ginseng seed has been mostly unused and discarded. As part of our ongoing research on the ginseng seeds, the inhibitory effect of ginseng seeds on melanin production was verified to assess their potential as a skin depigmenting substance. MATERIALS AND METHODS: The present study measured the inhibitory effect of ginseng seeds on melanin production through the tyrosinase inhibitory effect and analyzed their effects on melanin production in melan-a-cells. RESULTS: Ethanol extract of ginseng seed was applied to melan-a-cells at a concentration of 100 ppm and melanin production was reduced by 35.1% without cytotoxicity. In addition, the ethanol extract of ginseng seed was shown to reduce tyrosinase activity. CONCLUSION: Because the results showed excellent melanin inhibitory activity compared with that obtained by arbutin, ethanol extracts of ginseng leaf and ginseng root at the same concentration, it can be concluded that ginseng seeds show great potential as a skin depigmenting substance. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4078335/ /pubmed/24991102 http://dx.doi.org/10.4103/0973-1296.133271 Text en Copyright: © Pharmacognosy Magazine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Yeonmi
Kim, Kyoung-Tack
Kim, Sung Soo
Hur, Jinyoung
Ha, Sang Keun
Cho, Chang-Won
Choi, Sang Yoon
Inhibitory effects of ginseng seed on melanin biosynthesis
title Inhibitory effects of ginseng seed on melanin biosynthesis
title_full Inhibitory effects of ginseng seed on melanin biosynthesis
title_fullStr Inhibitory effects of ginseng seed on melanin biosynthesis
title_full_unstemmed Inhibitory effects of ginseng seed on melanin biosynthesis
title_short Inhibitory effects of ginseng seed on melanin biosynthesis
title_sort inhibitory effects of ginseng seed on melanin biosynthesis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078335/
https://www.ncbi.nlm.nih.gov/pubmed/24991102
http://dx.doi.org/10.4103/0973-1296.133271
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