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Medial open transversus abdominis plane (MOTAP) catheters for analgesia following open liver resection: study protocol for a randomized controlled trial
BACKGROUND: The current standard for pain control following liver surgery is intravenous, patient-controlled analgesia (IV PCA) or epidural analgesia. We have developed a modification of a regional technique called medial open transversus abdominis plane (MOTAP) catheter analgesia. The MOTAP techniq...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078361/ https://www.ncbi.nlm.nih.gov/pubmed/24950773 http://dx.doi.org/10.1186/1745-6215-15-241 |
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author | Karanicolas, Paul Cleary, Sean McHardy, Paul McCluskey, Stuart Sawyer, Jason Ladak, Salima Law, Calvin Wei, Alice Coburn, Natalie Ko, Raynauld Katz, Joel Kiss, Alex Khan, James Coimbatore, Srinivas Lam-McCulloch, Jenny Clarke, Hance |
author_facet | Karanicolas, Paul Cleary, Sean McHardy, Paul McCluskey, Stuart Sawyer, Jason Ladak, Salima Law, Calvin Wei, Alice Coburn, Natalie Ko, Raynauld Katz, Joel Kiss, Alex Khan, James Coimbatore, Srinivas Lam-McCulloch, Jenny Clarke, Hance |
author_sort | Karanicolas, Paul |
collection | PubMed |
description | BACKGROUND: The current standard for pain control following liver surgery is intravenous, patient-controlled analgesia (IV PCA) or epidural analgesia. We have developed a modification of a regional technique called medial open transversus abdominis plane (MOTAP) catheter analgesia. The MOTAP technique involves surgically placed catheters through the open surgical site into a plane between the internal oblique muscle and the transverse abdominis muscle superiorly. The objective of this trial is to assess the efficacy of this technique. METHODS/DESIGN: This protocol describes a multicentre, prospective, blinded, randomized controlled trial. One hundred and twenty patients scheduled for open liver resection through a subcostal incision will be enrolled. All patients will have two MOTAP catheters placed at the conclusion of surgery. Patients will be randomized to one of two parallel groups: experimental (local anaesthetic through MOTAP catheters) or placebo (normal saline through MOTAP catheters). Both groups will also receive IV PCA. The primary endpoint is mean cumulative postoperative opioid consumption over the first 2 postoperative days (48 hours). Secondary outcomes include pain intensity, patient functional outcomes, and the incidence of complications. DISCUSSION: This trial has been approved by the ethics boards at participating centres and is currently enrolling patients. Data collection will be completed by the end of 2014 with analysis mid-2015 and publication by the end of 2015. TRIAL REGISTRATION: The study is registered with http://clinicaltrials.gov ( NCT01960049; 23 September 2013) |
format | Online Article Text |
id | pubmed-4078361 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40783612014-07-03 Medial open transversus abdominis plane (MOTAP) catheters for analgesia following open liver resection: study protocol for a randomized controlled trial Karanicolas, Paul Cleary, Sean McHardy, Paul McCluskey, Stuart Sawyer, Jason Ladak, Salima Law, Calvin Wei, Alice Coburn, Natalie Ko, Raynauld Katz, Joel Kiss, Alex Khan, James Coimbatore, Srinivas Lam-McCulloch, Jenny Clarke, Hance Trials Study Protocol BACKGROUND: The current standard for pain control following liver surgery is intravenous, patient-controlled analgesia (IV PCA) or epidural analgesia. We have developed a modification of a regional technique called medial open transversus abdominis plane (MOTAP) catheter analgesia. The MOTAP technique involves surgically placed catheters through the open surgical site into a plane between the internal oblique muscle and the transverse abdominis muscle superiorly. The objective of this trial is to assess the efficacy of this technique. METHODS/DESIGN: This protocol describes a multicentre, prospective, blinded, randomized controlled trial. One hundred and twenty patients scheduled for open liver resection through a subcostal incision will be enrolled. All patients will have two MOTAP catheters placed at the conclusion of surgery. Patients will be randomized to one of two parallel groups: experimental (local anaesthetic through MOTAP catheters) or placebo (normal saline through MOTAP catheters). Both groups will also receive IV PCA. The primary endpoint is mean cumulative postoperative opioid consumption over the first 2 postoperative days (48 hours). Secondary outcomes include pain intensity, patient functional outcomes, and the incidence of complications. DISCUSSION: This trial has been approved by the ethics boards at participating centres and is currently enrolling patients. Data collection will be completed by the end of 2014 with analysis mid-2015 and publication by the end of 2015. TRIAL REGISTRATION: The study is registered with http://clinicaltrials.gov ( NCT01960049; 23 September 2013) BioMed Central 2014-06-21 /pmc/articles/PMC4078361/ /pubmed/24950773 http://dx.doi.org/10.1186/1745-6215-15-241 Text en Copyright © 2014 Karanicolas et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Study Protocol Karanicolas, Paul Cleary, Sean McHardy, Paul McCluskey, Stuart Sawyer, Jason Ladak, Salima Law, Calvin Wei, Alice Coburn, Natalie Ko, Raynauld Katz, Joel Kiss, Alex Khan, James Coimbatore, Srinivas Lam-McCulloch, Jenny Clarke, Hance Medial open transversus abdominis plane (MOTAP) catheters for analgesia following open liver resection: study protocol for a randomized controlled trial |
title | Medial open transversus abdominis plane (MOTAP) catheters for analgesia following open liver resection: study protocol for a randomized controlled trial |
title_full | Medial open transversus abdominis plane (MOTAP) catheters for analgesia following open liver resection: study protocol for a randomized controlled trial |
title_fullStr | Medial open transversus abdominis plane (MOTAP) catheters for analgesia following open liver resection: study protocol for a randomized controlled trial |
title_full_unstemmed | Medial open transversus abdominis plane (MOTAP) catheters for analgesia following open liver resection: study protocol for a randomized controlled trial |
title_short | Medial open transversus abdominis plane (MOTAP) catheters for analgesia following open liver resection: study protocol for a randomized controlled trial |
title_sort | medial open transversus abdominis plane (motap) catheters for analgesia following open liver resection: study protocol for a randomized controlled trial |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078361/ https://www.ncbi.nlm.nih.gov/pubmed/24950773 http://dx.doi.org/10.1186/1745-6215-15-241 |
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