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Hepatitis A seropositivity among newly admitted medical students of Isfahan, Kermanshah, and Hamedan: A seroprevalence study

BACKGROUND: Health science students are at an increased risk of hepatitis A virus (HAV) infection even under accidental infection. The aims of this study were to assess the seroprevalence of HAV in 1(st) year medical students and to determine the risk factors of HAV vaccination program among this po...

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Autores principales: Vakili, Bahareh, Rahimi, Hamid, Ataei, Behrooz, Janghorbani, Mohsen, Khorvash, Farzin, Shoaei, Parisa, Yaran, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078374/
https://www.ncbi.nlm.nih.gov/pubmed/25002901
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author Vakili, Bahareh
Rahimi, Hamid
Ataei, Behrooz
Janghorbani, Mohsen
Khorvash, Farzin
Shoaei, Parisa
Yaran, Majid
author_facet Vakili, Bahareh
Rahimi, Hamid
Ataei, Behrooz
Janghorbani, Mohsen
Khorvash, Farzin
Shoaei, Parisa
Yaran, Majid
author_sort Vakili, Bahareh
collection PubMed
description BACKGROUND: Health science students are at an increased risk of hepatitis A virus (HAV) infection even under accidental infection. The aims of this study were to assess the seroprevalence of HAV in 1(st) year medical students and to determine the risk factors of HAV vaccination program among this population. MATERIALS AND METHODS: A cross-sectional study was conducted in autumn 2010. A total of 1028 newly admitted medical students in Isfahan, Kermanshah and Hamedan were included in the study. Participant data were obtained through predesigned data collection sheets. A serum sample was obtained for serologic testing for the presence of IgG anti-HAV using a commercially available enzyme-linked immunosorbent assay kit. Descriptive statistics, Chi-square and logistic regression tests were performed for statistical analysis and P < 0.05 was considered as significant. RESULTS: The prevalence of HAV was detected in Isfahan, Hamedan, and Kermanshah newly admitted students 67.5%, 79.2%, and 50.6% respectively. There were significant relations between anti-HAV (IgG) positivity in drinking water and medical students provinces (P < 0.001, RR = 0.58 and 0.65 respectively). The household size did not significantly influence the anti-HAV (IgG) positivity in studied subjects (P = 0.09, RR = 1.26). CONCLUSION: Our results indicate that more than one-third of the medical students in all three faculties were seronegative for IgG anti-HAV and hence at an increased risk of developing HAV infection as a result of occupational exposure. Therefore, we suggest students in a health care set up should undergo vaccination against HAV after prevaccination immunity screening.
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spelling pubmed-40783742014-07-07 Hepatitis A seropositivity among newly admitted medical students of Isfahan, Kermanshah, and Hamedan: A seroprevalence study Vakili, Bahareh Rahimi, Hamid Ataei, Behrooz Janghorbani, Mohsen Khorvash, Farzin Shoaei, Parisa Yaran, Majid J Res Med Sci Original Article BACKGROUND: Health science students are at an increased risk of hepatitis A virus (HAV) infection even under accidental infection. The aims of this study were to assess the seroprevalence of HAV in 1(st) year medical students and to determine the risk factors of HAV vaccination program among this population. MATERIALS AND METHODS: A cross-sectional study was conducted in autumn 2010. A total of 1028 newly admitted medical students in Isfahan, Kermanshah and Hamedan were included in the study. Participant data were obtained through predesigned data collection sheets. A serum sample was obtained for serologic testing for the presence of IgG anti-HAV using a commercially available enzyme-linked immunosorbent assay kit. Descriptive statistics, Chi-square and logistic regression tests were performed for statistical analysis and P < 0.05 was considered as significant. RESULTS: The prevalence of HAV was detected in Isfahan, Hamedan, and Kermanshah newly admitted students 67.5%, 79.2%, and 50.6% respectively. There were significant relations between anti-HAV (IgG) positivity in drinking water and medical students provinces (P < 0.001, RR = 0.58 and 0.65 respectively). The household size did not significantly influence the anti-HAV (IgG) positivity in studied subjects (P = 0.09, RR = 1.26). CONCLUSION: Our results indicate that more than one-third of the medical students in all three faculties were seronegative for IgG anti-HAV and hence at an increased risk of developing HAV infection as a result of occupational exposure. Therefore, we suggest students in a health care set up should undergo vaccination against HAV after prevaccination immunity screening. Medknow Publications & Media Pvt Ltd 2014-03 /pmc/articles/PMC4078374/ /pubmed/25002901 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Vakili, Bahareh
Rahimi, Hamid
Ataei, Behrooz
Janghorbani, Mohsen
Khorvash, Farzin
Shoaei, Parisa
Yaran, Majid
Hepatitis A seropositivity among newly admitted medical students of Isfahan, Kermanshah, and Hamedan: A seroprevalence study
title Hepatitis A seropositivity among newly admitted medical students of Isfahan, Kermanshah, and Hamedan: A seroprevalence study
title_full Hepatitis A seropositivity among newly admitted medical students of Isfahan, Kermanshah, and Hamedan: A seroprevalence study
title_fullStr Hepatitis A seropositivity among newly admitted medical students of Isfahan, Kermanshah, and Hamedan: A seroprevalence study
title_full_unstemmed Hepatitis A seropositivity among newly admitted medical students of Isfahan, Kermanshah, and Hamedan: A seroprevalence study
title_short Hepatitis A seropositivity among newly admitted medical students of Isfahan, Kermanshah, and Hamedan: A seroprevalence study
title_sort hepatitis a seropositivity among newly admitted medical students of isfahan, kermanshah, and hamedan: a seroprevalence study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078374/
https://www.ncbi.nlm.nih.gov/pubmed/25002901
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