Cargando…

IBP regulates epithelial-to-mesenchymal transition and the motility of breast cancer cells via Rac1, RhoA and Cdc42 signaling pathways

Epithelial-to-mesenchymal transition (EMT) is a crucial process for the invasion and metastasis of epithelial tumors. However, the molecular mechanisms underlying this transition are poorly understood. In this study, we demonstrate that interferon regulatory factor 4 binding protein (IBP) regulates...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Z, Yang, M, Chen, R, Su, W, Li, P, Chen, S, Chen, Z, Chen, A, Li, S, Hu, C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078416/ https://www.ncbi.nlm.nih.gov/pubmed/23975422 http://dx.doi.org/10.1038/onc.2013.337

Ejemplares similares

Spatio-temporal co-ordination of RhoA, Rac1 and Cdc42 activation during prototypical edge protrusion and retraction dynamics
por: Martin, Katrin, et al.
Publicado: (2016)

RhoA and Cdc42 in T cells: Are they targetable for T cell-mediated inflammatory diseases?
por: Guo, Fukun
Publicado: (2021)

MicroRNA-122 Triggers Mesenchymal-Epithelial Transition and Suppresses Hepatocellular Carcinoma Cell Motility and Invasion by Targeting RhoA
por: Wang, Sheng-Chun, et al.
Publicado: (2014)

MgcRacGAP restricts active RhoA at the cytokinetic furrow and both RhoA and Rac1 at cell–cell junctions in epithelial cells
por: Breznau, Elaina B., et al.
Publicado: (2015)

Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury
por: Blattner, Simone M., et al.
Publicado: (2013)

Concentric zones of active RhoA and Cdc42 around single cell wounds
por: Benink, Hélène A., et al.
Publicado: (2005)

RhoA/ROCK pathway mediates the effect of oestrogen on regulating epithelial‐mesenchymal transition and proliferation in endometriosis
por: Huang, Zhi‐Xiong, et al.
Publicado: (2020)

Ang II-AT2R increases mesenchymal stem cell migration by signaling through the FAK and RhoA/Cdc42 pathways in vitro
por: Xu, Xiu-ping, et al.
Publicado: (2017)

Cell type-specific roles for Cdc42, Rac, and RhoL in Drosophila oogenesis
Publicado: (1996)

MDA-9/Syntenin (SDCBP) modulates small GTPases RhoA and Cdc42 via transforming growth factor β1 to enhance epithelial-mesenchymal transition in breast cancer
por: Menezes, Mitchell E., et al.
Publicado: (2016)

Plexin-B2 Negatively Regulates Macrophage Motility, Rac, and Cdc42 Activation
por: Roney, Kelly E., et al.
Publicado: (2011)

The BNIP-2 and Cdc42GAP Homology (BCH) Domain of p50RhoGAP/Cdc42GAP Sequesters RhoA from Inactivation by the Adjacent GTPase-activating Protein Domain
por: Zhou, Yi Ting, et al.
Publicado: (2010)

Epigenetically upregulated GEFT-derived invasion and metastasis of rhabdomyosarcoma via epithelial mesenchymal transition promoted by the Rac1/Cdc42-PAK signalling pathway
por: Liu, Chunxia, et al.
Publicado: (2019)

Evidence for a Novel Mechanism of the PAK1 Interaction with the Rho-GTPases Cdc42 and Rac
por: Shin, Yong Jae, et al.
Publicado: (2013)

eIF3a Regulates Colorectal Cancer Metastasis via Translational Activation of RhoA and Cdc42
por: Mei, Chao, et al.
Publicado: (2022)

Retraction Note: Ang II-AT2R increases mesenchymal stem cell migration by signaling through the FAK and RhoA/Cdc42 pathways in vitro
por: Xu, Xiu-ping, et al.
Publicado: (2022)

Poria cocos Regulates Cell Migration and Actin Filament Aggregation in B35 and C6 Cells by Modulating the RhoA, CDC42, and Rho Signaling Pathways
por: Lee, Chia-Yu, et al.
Publicado: (2021)

The role of Rho GTPases’ substrates Rac and Cdc42 in osteoclastogenesis and relevant natural medicinal products study
por: Liu, Yuan, et al.
Publicado: (2020)

The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA
por: Sakurai-Yageta, Mika, et al.
Publicado: (2008)

A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis
por: Dütting, Sebastian, et al.
Publicado: (2017)

RhoA- and Cdc42-induced antagonistic forces underlie symmetry breaking and spindle rotation in mouse oocytes
por: Dehapiot, Benoit, et al.
Publicado: (2021)

The balance between Gα(i)-Cdc42/Rac and Gα(1)(2)/(1)(3)-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate
por: Reinhard, Nathalie R., et al.
Publicado: (2017)

The three-way switch operation of Rac1/RhoA GTPase-based circuit controlling amoeboid-hybrid-mesenchymal transition
por: Huang, Bin, et al.
Publicado: (2014)

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches
por: Byrne, Kate M., et al.
Publicado: (2016)

Rho Family Gtpase Cdc42 Is Essential for the Actin-Based Motility of Shigella in Mammalian Cells
por: Suzuki, Toshihiko, et al.
Publicado: (2000)

Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac
por: Fang, Xiang, et al.
Publicado: (2004)

Shear stress–induced endothelial cell polarization is mediated by Rho and Rac but not Cdc42 or PI 3-kinases
por: Wojciak-Stothard, Beata, et al.
Publicado: (2003)

To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front
por: Van Keymeulen, Alexandra, et al.
Publicado: (2006)

Cdc42 and RhoA reveal different spatio-temporal dynamics upon local stimulation with Semaphorin-3A
por: Iseppon, Federico, et al.
Publicado: (2015)

The evolutionary history of effectors downstream of Cdc42 and Rac
por: Cotteret, Sophie, et al.
Publicado: (2002)

Targeting Rac and Cdc42 GEFs in Metastatic Cancer
por: Maldonado, Maria del Mar, et al.
Publicado: (2020)

Roles of the small GTPases RhoA and Rac1 in cell behavior
por: Otey, Carol, et al.
Publicado: (2009)

Compromized geranylgeranylation of RhoA and Rac1 in mevalonate kinase deficiency
por: Henneman, L., et al.
Publicado: (2010)

MiR-1301-3p Inhibits Epithelial-Mesenchymal Transition via Targeting RhoA in Pancreatic Cancer
por: Zhang, Xinxue, et al.
Publicado: (2022)

RhoA/Rho-kinase triggers epithelial-mesenchymal transition in mesothelial cells and contributes to the pathogenesis of dialysis-related peritoneal fibrosis
por: Wang, Qinglian, et al.
Publicado: (2018)

NKCC1 promotes EMT‐like process in GBM via RhoA and Rac1 signaling pathways
por: Ma, Haiwen, et al.
Publicado: (2018)

Desmoglein 3 acting as an upstream regulator of Rho GTPases, Rac-1/Cdc42 in the regulation of actin organisation and dynamics
por: Man Tsang, Siu, et al.
Publicado: (2012)

RhoG and Cdc42 can contribute to Rac-dependent lamellipodia formation through WAVE regulatory complex-binding
por: Schaks, Matthias, et al.
Publicado: (2019)

Rac and Rho GTPases in cancer cell motility control
por: Parri, Matteo, et al.
Publicado: (2010)

Actin-Mediated Gene Expression Depends on RhoA and Rac1 Signaling in Proximal Tubular Epithelial Cells
por: Giehl, Klaudia, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_1of6c6sh2jl6pb11pktpea34a5