Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence

Cellular senescence is an irreversible side effect of some pharmaceuticals which can contribute to tissue degeneration. OBJECTIVE: To determine whether pharmaceutical glucocorticoids induce senescence in tenocytes. METHODS: Features of senescence (β-galactosidase activity at pH 6 (SA-β-gal) and acti...

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Detalles Bibliográficos
Autores principales: Poulsen, Raewyn C, Watts, Anna C, Murphy, Richard J, Snelling, Sarah J, Carr, Andrew J, Hulley, Philippa A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2014
Materias:
Basic and Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078757/
https://www.ncbi.nlm.nih.gov/pubmed/23727633
http://dx.doi.org/10.1136/annrheumdis-2012-203146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078757/
https://www.ncbi.nlm.nih.gov/pubmed/23727633
http://dx.doi.org/10.1136/annrheumdis-2012-203146

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