Cargando…

The molecular basis for ethnic variation and histological subtype differences in prostate cancer

Prostate cancer is a common malignancy among men in Western countries. Recently the morbidity and mortality of prostate cancer increase dramatically in several oriental countries including China. Rapidly evolving technology in molecular biology such as high-throughput sequencing and integrative anal...

Descripción completa

Detalles Bibliográficos
Autores principales: ZONG, Yang, GOLDSTEIN, Andrew S., HUANG, JiaoTi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078990/
https://www.ncbi.nlm.nih.gov/pubmed/23852643
http://dx.doi.org/10.1007/s11427-013-4522-0
_version_ 1782323804429615104
author ZONG, Yang
GOLDSTEIN, Andrew S.
HUANG, JiaoTi
author_facet ZONG, Yang
GOLDSTEIN, Andrew S.
HUANG, JiaoTi
author_sort ZONG, Yang
collection PubMed
description Prostate cancer is a common malignancy among men in Western countries. Recently the morbidity and mortality of prostate cancer increase dramatically in several oriental countries including China. Rapidly evolving technology in molecular biology such as high-throughput sequencing and integrative analysis of genomic and transcriptomic landscapes have enabled the identification of key oncogenic events for prostate cancer initiation, progression and resistance to hormonal therapy. These surging data of prostate cancer genome also provide insights on ethnic variation and the differences in histological subtype of this disease. In this review, differences in the incidence of prostate cancer and the prevalence of main genetic alterations between Asian and Western populations are discussed. We also review the recent findings on the mechanisms underlying neuroendocrine differentiation of prostate cancer and the development of small cell neuroendocrine carcinoma after androgen deprivation therapy.
format Online
Article
Text
id pubmed-4078990
institution National Center for Biotechnology Information
language English
publishDate 2013
record_format MEDLINE/PubMed
spelling pubmed-40789902014-07-02 The molecular basis for ethnic variation and histological subtype differences in prostate cancer ZONG, Yang GOLDSTEIN, Andrew S. HUANG, JiaoTi Sci China Life Sci Article Prostate cancer is a common malignancy among men in Western countries. Recently the morbidity and mortality of prostate cancer increase dramatically in several oriental countries including China. Rapidly evolving technology in molecular biology such as high-throughput sequencing and integrative analysis of genomic and transcriptomic landscapes have enabled the identification of key oncogenic events for prostate cancer initiation, progression and resistance to hormonal therapy. These surging data of prostate cancer genome also provide insights on ethnic variation and the differences in histological subtype of this disease. In this review, differences in the incidence of prostate cancer and the prevalence of main genetic alterations between Asian and Western populations are discussed. We also review the recent findings on the mechanisms underlying neuroendocrine differentiation of prostate cancer and the development of small cell neuroendocrine carcinoma after androgen deprivation therapy. 2013-07-13 2013-09 /pmc/articles/PMC4078990/ /pubmed/23852643 http://dx.doi.org/10.1007/s11427-013-4522-0 Text en © The Author(s) 2013. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
ZONG, Yang
GOLDSTEIN, Andrew S.
HUANG, JiaoTi
The molecular basis for ethnic variation and histological subtype differences in prostate cancer
title The molecular basis for ethnic variation and histological subtype differences in prostate cancer
title_full The molecular basis for ethnic variation and histological subtype differences in prostate cancer
title_fullStr The molecular basis for ethnic variation and histological subtype differences in prostate cancer
title_full_unstemmed The molecular basis for ethnic variation and histological subtype differences in prostate cancer
title_short The molecular basis for ethnic variation and histological subtype differences in prostate cancer
title_sort molecular basis for ethnic variation and histological subtype differences in prostate cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078990/
https://www.ncbi.nlm.nih.gov/pubmed/23852643
http://dx.doi.org/10.1007/s11427-013-4522-0
work_keys_str_mv AT zongyang themolecularbasisforethnicvariationandhistologicalsubtypedifferencesinprostatecancer
AT goldsteinandrews themolecularbasisforethnicvariationandhistologicalsubtypedifferencesinprostatecancer
AT huangjiaoti themolecularbasisforethnicvariationandhistologicalsubtypedifferencesinprostatecancer
AT zongyang molecularbasisforethnicvariationandhistologicalsubtypedifferencesinprostatecancer
AT goldsteinandrews molecularbasisforethnicvariationandhistologicalsubtypedifferencesinprostatecancer
AT huangjiaoti molecularbasisforethnicvariationandhistologicalsubtypedifferencesinprostatecancer